AI-enhanced adaptive virtual screening of large libraries for ligand discovery

Nature Biotechnology - Issue - nature.com science feeds

By: Domiziana Cecchini · AkshatKumar Nigam · Ming Tang · Joana Reis · Matt Koop · Andrea Gottinger · Callum Robert Nicoll · Yao Wang · Abhilash Jayaraj · Süleyman Selim Çınaroglu˘ · Ricarda Törner · Yehor Malets · Minko Gehev · Krishna M. Padmanabha Das · Kelly Churion · Jongwan Kim · Nidhin Thomas · Yong Li · Hyuk-Soo Seo · Sirano Dhe-Paganon · Christopher Secker · Mohammad Haddadnia · Alexander Hasson · Minkai Li · Abhishek Kumar · Roni Levin-Konigsberg · Eun-Bee Choi · Geoffrey I. Shapiro · Huel Cox 3rd · Luke Sebastian · Chelsea Braithwaite · Puspalata Bashyal · Dmytro S. Radchenko · Aditya Kumar · Lei Yang · Pierre-Yves Aquilanti · Henry Gabb · Amr Alhossary · Eric O’Neill · Gerhard Wagner · Alán Aspuru-Guzik · Yurii S. Moroz · Charalampos G. Kalodimos · Konstantin Fackeldey · John D. Schuetz · Andrea Mattevi · Haribabu Arthanari · Christoph Gorgulla

1 September 2026 at 08:00

Nature Biotechnology, Published online: 01 September 2026; doi:10.1038/s41587-026-03217-x

Massive chemical libraries are screened computationally at scale.

NDRG2 orchestrates circadian clock stability to suppress tumorigenesis and potentiate oxaliplatin response in colorectal cancer

Oncogene - Issue - nature.com science feeds

By: Ruikai Li · Ruxin Ding · Hanjun Dan · Kunli Du · Gaozan Zheng · Siyuan Wang · Lili Duan · Pengfei Wang · Liangliang Shen · Lin Feng · Pan Zhao · Jiajia Wang · Dan Feng · Fengsu Wu · Yumao Yang · Ziting Zhou · Liaoran Niu · Weidong Wang · Xinyu Qiao · Jianting Yang · Fan Feng · Jianyong Zheng · Jian Zhang

19 May 2026 at 08:00

Oncogene, Published online: 19 May 2026; doi:10.1038/s41388-026-03823-8

NDRG2 orchestrates circadian clock stability to suppress tumorigenesis and potentiate oxaliplatin response in colorectal cancer

Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome

Nature - Issue - nature.com science feeds

By: Jianping Liu · Jing Zhao · Jiayang Gao · Kun Zhao · Yaoyao Han · Jing Yang · Zefei Li · Jianyu Ye · Ziyu Sun · Fengyi Wang · Xinyi Liu · Zekai Li · Siyu Ji · Bo Liu · Cong Liu · Yixiao Zhang · Junying Yuan · James J. Chou

1 April 2026 at 08:00

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10304-1

Long-range interactions mediated by protein electric dipole moments have a role in driving the assembly and disassembly of super-signalling complex I for promoting NF-κB signalling.

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