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Highly efficient base editing at <i>PCSK9</i> and normal human embryo development
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11118-x
Highly efficient base editing at PCSK9 and normal human embryo development
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PRET is a few-shot system for pan-cancer recognition without example training
Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-026-01141-2
Li et al. present PRET, a few-shot system for pan-cancer detection not requiring model fine-tuning, validated it in multicenter datasets and found that it outperformed existing approaches across tasks and pathologists in lymph node metastasis detection.
Hijacking ERAD for targeted degradation of transmembrane proteins
Development of an ERAD-hijacking technology overcomes the challenges of current targeted protein degradation approaches to achieve degradation of transmembrane proteins.
