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AI-enhanced adaptive virtual screening of large libraries for ligand discovery
Nature Biotechnology, Published online: 01 September 2026; doi:10.1038/s41587-026-03217-x
Massive chemical libraries are screened computationally at scale.
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Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer
By selectively targeting peripheral 5-HT2AR without inducing psychedelic effects, a non-brain-penetrant agonist boosts antitumor CD8+ T cell immunity and improves immunotherapy responses in preclinical models of colorectal cancer.
Asymmetric selection of a rice immune module and rebuild of disease resistance
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10361-6
Stacking XA48-mediated effector-triggered immunity with XA21-mediated pattern-triggered immunity in Oryza sativa japonica reconstitutes the broad-spectrum resistance from wild rice.
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons
(Cell 188, 6283–6300.e1–e10; October 30, 2025)
