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Data-driven identification of repurposable drugs for ALS
npj Digital Medicine, Published online: 14 September 2026; doi:10.1038/s41746-026-03225-w
Data-driven identification of repurposable drugs for ALS
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Multi-omic profiling reveals metabolic vulnerabilities in enzalutamide resistant prostate cancer
Cell Death Discovery, Published online: 09 September 2026; doi:10.1038/s41420-026-03332-3
Multi-omic profiling reveals metabolic vulnerabilities in enzalutamide resistant prostate cancer
PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10954-1
A specific population of macrophages that express high levels of the enzyme PLA2G2D in tumour-draining lymph nodes is associated with poor prognosis in patients, and inhibiting PLA2G2D improves anti-tumour immunity in mouse models.
Imaging cellular activity across all organs reveals body-wide circuits
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10979-6
An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.
TRI-611, a selective, brain-penetrant molecular glue degrader of ALK
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10998-3
TRI-611 induces the degradation of ALK fusion proteins via a previously undescribed CRBN recruitment motif, and its preclinical anti-tumour activity highlights TRI-611 as a potential new way of treating ALK-positive non-small-cell lung cancer.
Integrated signatures define mutational processes in prostate cancer
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10468-w
Eight integrated mutational footprints collectively explain the mutational processes in 85% of primary prostate cancer genomes.
TM184C is a GPCR-like regulator of intercellular exchange and autophagy
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10993-8
TM184C—an ancient G-protein-coupled receptor-like superdark protein involved in regulation of autophagy, intercellular connectivity and material exchange—underscores the promise of exploring the understudied human proteome and beyond.
Consensus framework for the validation of generative AI: call for collaborators on the Validation Accords
Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04647-5
Consensus framework for the validation of generative AI: call for collaborators on the Validation Accords
Inhaled siRNA therapy targeting RAGE for pulmonary inflammation: a first-in-human randomized trial
Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04607-z
Following preclinical development, a randomized first-in-human trial showed that treatment with an inhaled, lung-epithelium-targeted siRNA directed against the receptor for advanced glycation end-products (RAGE) was safe and well tolerated and reduced RAGE levels in serum and bronchoalveolar lavage fluid.
Myeloperoxidase inhibition with mitiperstat in heart failure with preserved or mildly reduced ejection fraction: a randomized phase 2b trial
Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04615-z
In a phase 2 randomized clinical trial, treatment with the myeloperoxidase (MPO) inhibitor mitiperstat, intended to target the neutrophil–MPO inflammatory pathway, did not improve symptoms or exercise function in individuals with heart failure with preserved or mildly reduced ejection fraction.
A global framework for artificial intelligence education in medicine: international working group recommendations
npj Digital Medicine, Published online: 09 September 2026; doi:10.1038/s41746-026-03197-x
A global framework for artificial intelligence education in medicine: international working group recommendations
Limit bets on clinical-trial outcomes being placed on prediction markets
Nature, Published online: 08 September 2026; doi:10.1038/d41586-026-02795-9
Limit bets on clinical-trial outcomes being placed on prediction markets
Integration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment
Nature Biotechnology, Published online: 07 September 2026; doi:10.1038/s41587-026-03286-y
Six proteomic clocks are applied in a clinical trial to assess anti-aging effects.
A step-wise, deterministic and fatal mouse model of myeloid neoplasm with spontaneous acquisition of patient-relevant RTK–RAS mutations
Oncogene, Published online: 04 September 2026; doi:10.1038/s41388-026-03964-w
A step-wise, deterministic and fatal mouse model of myeloid neoplasm with spontaneous acquisition of patient-relevant RTK–RAS mutations
Sexual dimorphism in the complete Drosophila male central nervous system connectome
The Drosophila whole male central nervous system connectome enables end-to-end analysis of sensorimotor circuits. Comparison with existing female datasets shows that brain-wide wiring differences between the sexes are concentrated in higher centers.
The complete gustatory connectome of adult Drosophila reveals how taste guides feeding, foraging, and social behavior
The complete gustatory system and the full set of feeding motor neurons of adult Drosophila are mapped at synaptic resolution, enabling the identification of taste neuron types and their likely tastants and showing how valence-specific circuit motifs route taste to generate distinct feeding, neuroendocrine, and social outputs.
Publisher Correction: Adjuvant personalized multivalent neoantigen DNA vaccination for MGMT unmethylated glioblastoma: a phase 1 trial
Nature Cancer, Published online: 01 September 2026; doi:10.1038/s43018-026-01243-x
Publisher Correction: Adjuvant personalized multivalent neoantigen DNA vaccination for MGMT unmethylated glioblastoma: a phase 1 trial
Neuromedin U ‘innervation’ reprograms myeloid immunosuppression in neuroendocrine prostate cancer
Oncogene, Published online: 01 September 2026; doi:10.1038/s41388-026-03969-5
Neuromedin U ‘innervation’ reprograms myeloid immunosuppression in neuroendocrine prostate cancer