Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04265-1

In this phase 1, open-label dose-escalation study in healthy adults found that the mRNA vaccine (mRNA-1215), encoding the Nipah virus Malaysian strain chimeric pre-fusion F protein linked to glycoprotein G, was safe and induced elevated immune responses at 1 year of follow-up, indicating that this is a promising vaccine candidate for further development.

Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04252-6

The authors propose a framework for clinical AI evaluation within simulated digital hospital environments that capture the evolving constraints, and cascading effects, of clinical decisions.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10228-w

Conventional and time-resolved cryo-electron microscopy reveal how NTSR1 dynamically engages and releases different G proteins, capturing over 20 intermediates and uncovering key mechanistic steps in GDP- and GTP-driven activation, subtype selectivity and distinct dissociation pathways.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10214-2

Individual supratentorial ependymoma tumour subgroups have two distinct progenitor-like cell states—neuroepithelial-like and embryonic-like—that are reminiscent of early human brain development and diverge in the extent of their neuronal or ependymal differentiation.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10151-0

Observations of a nearby type I superluminous supernova showing oscillating light-curve bumps provide evidence of a centrally located magnetar in the wake of the explosion, surrounded by an infalling accretion disk undergoing Lense–Thirring precession.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10120-7

Time-resolved cryo-electron microscopy during activation of Gαi1βγ and Gα11βγ heterotrimers bound to NTSR1 enables isolation of multiple transient complexes along the activation pathway and reveals structural motifs that stabilize these intermediates.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10191-6

Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this gut–brain pathway restores memory in aged mice.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10229-9

A pangenome reference for the phenotypically diverse crop sorghum aims to help accelerate future efforts to breed crops that are better adapted to changing environments.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10248-6

Imprinting by influenza viruses can cause a deleterious shift of nearly the entire memory recall response against key, conserved epitopes.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-025-10038-6

A monolithically integrated photonic ski-jump enables scalable, diffraction-limited 2D beam scanning from photonic chips, achieving ultrahigh spot rates, compact footprints and applications spanning displays, sensing and quantum photonics.

Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04288-8

Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10241-z

INSTALL overcomes fundamental challenges for DNA delivery and integration methods by synergizing immune-stealth nucleic acids with recombinases to enable kilobase-scale integration strategies without viral vectors.

Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04241-9

This Review highlights insights from recent clinical trials and discusses critical factors for optimizing cancer vaccines, with a focus on proxies for vaccine efficacy, neoantigen selection, modular platforms and early intervention.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10225-z

Neonatal sepsis caused by Escherichia coli is associated with reduced transfer of pathogen-specific maternal antibodies and, in a mouse model, can be prevented by maternal preconceptual colonization with probiotic E. coli.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10216-0

Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrated stress response, and a therapeutic opportunity in older patients is revealed.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10256-6

Myelopoiesis in response to a parasitic worm infection and the mechanism selective to this form of parasite are revealed.

Nature Cancer, Published online: 10 March 2026; doi:10.1038/s43018-026-01127-0

Kelly et al. assessed an artificial intelligence system for breast cancer screening in retrospective datasets, followed by prospective feasibility evaluation, and report its accuracy, fairness and clinical implementation in multiple workflow settings.

Nature Cancer, Published online: 10 March 2026; doi:10.1038/s43018-026-01128-z

Warren et al. used data from a retrospective cohort of 50,000 women attending breast screening. Arbitration between human and AI decisions was performed in a reader study following normal arbitration workflow. After arbitration, replacing the second human reader with AI in a double-read breast screening workflow was noninferior to two human readers.