Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10310-3

DNA damage burden and inadequate repair in CUX2+ cortical layer 2/3 excitatory neurons contributes to selective vulnerability in neuroinflammatory injury.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10313-0

Findings suggest that neural crest fate bias predominantly emerges within the neural tube, and that only a minor subset of delaminated progenitors retain multipotency to generate both sensory and sympathetic derivatives.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10299-9

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10359-0

LIGO–Virgo–KAGRA’s fourth Gravitational-Wave Transient Catalog shows evidence of a clear pair-instability gap in the distribution of binary black-hole secondary masses but is absent in the larger primary masses.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10290-4

The transcription factor ATF4 is shown to regulate double-stranded DNA repair within vulnerable CUX2+ upper-layer 2/3 cortical neurons, enabling their survival during development.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10295-z

AhR functions as a neuronal brake on axon regeneration, integrating environmental sensing, protein homeostasis and metabolic signalling to control the balance between stress adaptation and axonal repair.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10203-5

A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10340-x

The seventh cholera pandemic, driven by El Tor Vibrio cholerae, evolved separately in Bangladesh and India, with the Ganges Basin acting as the global source, and its evolution has been shaped by phage defence system changes, influencing severity and transmission.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-025-09844-9

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Nature, Published online: 01 April 2026; doi:10.1038/d41586-026-00805-4

Three experts discuss lessons learnt from a large-scale dissection of the reproducibility, analytical robustness and replicability of published results.

Nature, Published online: 31 March 2026; doi:10.1038/d41586-026-00901-5

The month’s sharpest science shots, selected by Nature’s photo team.

Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03074-8

Unpaired data as a first-order challenge in single-cell and spatial proteomics