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Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons

βœ‡Cell
By: Shuai Jin Β· Zixu Zhu Β· Yunjia Li Β· Shouyue Zhang Β· Yijing Liu Β· Danyuan Li Β· Yuanqing Li Β· Yingfeng Luo Β· Zhiheng Cheng Β· Kevin Tianmeng Zhao Β· Qiang Gao Β· Guanglei Yang Β· Hongchao Li Β· Ronghong Liang Β· Rui Zhang Β· Jin-Long Qiu Β· Yong E. Zhang Β· Jun-Jie Gogo Liu Β· Caixia Gao
(Cell 188, 6283–6300.e1–e10; October 30, 2025)
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Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice

βœ‡Cell
By: Haijiao Zhao Β· Meimei Liao Β· Ran Huo Β· Ting He Β· Hongni Tian Β· Zeqi Li Β· Chen Chen Β· Ziqing Yu Β· Juan Chai Β· Xiaocui Song Β· Ruichao Shao Β· Shuhua Ying Β· Wen Gao Β· Ling Liu Β· Di Sang Β· Qi Li Β· Haohong Li Β· Fengchao Wang Β· Dapeng Ju Β· Eric Erquan Zhang
Enhancing circadian amplitude in mouse hypothalamic paraventricular nucleus neurons by 3β€²-deoxyadenosine treatment alleviates age-related pathologies and extends lifespan.
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