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Plasmin promotes hepatocellular carcinoma invasion and metastasis via CXCR4-mediated activation of PI3K/AKT/mTOR signaling

βœ‡Oncogene - Issue - nature.com science feeds
By: Zhiyuan Shen Β· Yuexing Yang Β· Tianyu Mao Β· Fangyan Wu Β· Fengming Li Β· Liu Yang Β· Min Yu Β· Bing Zhao

Oncogene, Published online: 09 April 2026; doi:10.1038/s41388-026-03775-z

Plasmin promotes hepatocellular carcinoma invasion and metastasis via CXCR4-mediated activation of PI3K/AKT/mTOR signaling
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Engineered immunosuppressive dendritic cells protect against cardiac remodelling

βœ‡Nature - Issue - nature.com science feeds
By: Xiaoying Li Β· Jiamin Li Β· Guohua Li Β· Lisheng Zhu Β· Guo Cheng Β· Huanqiang Li Β· Hao Lin Β· Ningqing Jia Β· Xiaoqian Hong Β· Ye Liu Β· Zhiwei Zhong Β· Yize Chen Β· Biqing Wang Β· Jing Zhao Β· Zhenqi Hua Β· Lingjun Wang Β· Qiming Chen Β· Peijie Zheng Β· Shuyuan Sheng Β· Songting Gu Β· Cheng Ni Β· Shuchang Ye Β· Changle Ke Β· Feimu Zhang Β· Mo Li Β· Shaohui Shi Β· Junhua He Β· Yan Wu Β· Yinghui Xu Β· Minjian Kong Β· Qi Chen Β· Huajun Li Β· Yu Zhang Β· Jianzhong Sun Β· Guanhua Hu Β· Chengchen Zhao Β· Yiping Dong Β· Lili Yu Β· Yang Xu Β· Xinyang Hu

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10346-5

Lesion-targeted immune modulation is a feasible strategy to control cardiac fibrosis, and engineered dendritic cells are a promising therapeutic platform for treating cardiac remodelling and heart failure.
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