knockout-induced hyperglycemia promotes spontaneous lung adenocarcinomas through HSF1-MDM2

Oncogene - Issue - nature.com science feeds

By: Yiwei Cao · Jingyi Wei · Qiang Chen · Haitao Wang · Jiao Mu · Shuhan Lu · Menghui Yuan · Mohammed A. El-Magd · Bichan Xu · Ruihong Wang · Peng Yuan

24 May 2026 at 08:00

Oncogene, Published online: 24 May 2026; doi:10.1038/s41388-026-03826-5

Liver-specific SIRT1 knockout-induced hyperglycemia promotes spontaneous lung adenocarcinomas through HSF1-MDM2

Accelerating scientific discovery with Co-Scientist

Nature - Issue - nature.com science feeds

By: Juraj Gottweis · Wei-Hung Weng · Alexander Daryin · Tao Tu · Petar Sirkovic · Artiom Myaskovsky · Grzegorz Glowaty · Felix Weissenberger · Alessio Orlandi · Dan Popovici · Anil Palepu · Keran Rong · Ryutaro Tanno · Khaled Saab · Fan Zhang · Jacob Blum · Andrew Carroll · Kavita Kulkarni · Nenad Tomašev · Dina Zverinski · Ivor Rendulic · Elahe Vedadi · Florian Hasler · Luka Rimanic · Marina Boia · Ivan Budiselic · Ben Feinstein · Mathias Bellaiche · Tom Sheffer · Jan Freyberg · Jeremy Ratcliff · Ottavia Bertolli · Katherine Chou · Avinatan Hassidim · Burak Gokturk · Amin Vahdat · Yuan Guan · Vikram Dhillon · Eeshit Dhaval Vaishnav · Byron Lee · Tiago R. D. Costa · José R. Penadés · Gary Peltz · Yossi Matias · James Manyika · Demis Hassabis · Yunhan Xu · Pushmeet Kohli · Annalisa Pawlosky · Alan Karthikesalingam · Vivek Natarajan

19 May 2026 at 08:00

Nature, Published online: 19 May 2026; doi:10.1038/s41586-026-10644-y

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Mapping convergent regulators of melanoma drug resistance by PerturbFate

Nature - Issue - nature.com science feeds

By: Zihan Xu · Ziyu Lu · Aileen Ugurbil · Abdulraouf Abdulraouf · Andrew Liao · Jianxiang Zhang · Wei Zhou · Junyue Cao

15 April 2026 at 08:00

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10367-0

PerturbFate is a high-throughput, cost-effective, single-cell platform that systematically profiles CRISPR interference perturbations to reveal common regulatory nodes and convergent phenotypic states across diverse genetic alterations linked to vemurafenib resistance in melanoma cells.

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