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A comparison of deep multiomics profiles across ethnicity, geography, and age

Multiomics profiling of healthy individuals reveals differences across molecular layers and key pathways related to immune, metabolic, and microbiome-linked processes across ethnicities, while geographic relocation reshapes these networks and influences aging trajectories.
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Fronto-insular circuit mechanisms of accelerated intermittent theta burst stimulation

An optogenetic model of accelerated intermittent theta burst stimulation reveals cell type-specific plasticity mechanisms and a key role for a fronto-insular circuit in driving the antidepressant effects of this treatment in humans.
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The spatiotemporal dynamics of postnatal vascularization in the mouse brain

Whole-brain tissue clearing and spatial transcriptomics were applied to map postnatal vascular development in the mouse brain, identifying three coordinated phases that link vascular growth to neuronal maturation.
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Controlled human influenza infection reveals heterogeneous expulsion of infectious virus into air

A platform called MIST enables quantification and genotyping of infectious influenza in expelled respiratory particles, revealing diverse, individual-specific viral loads and aerosolized variants that correlate with saliva and nasopharyngeal viral loads and symptoms. Overall, the findings indicate heterogeneity in transmission potential.
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