Cell Death Discovery, Published online: 16 September 2026; doi:10.1038/s41420-026-03349-8

ESAM reduces sensitivity to anti-HER2 therapy in HER2-positive breast cancer by activating the mTOR pathway

Cell Death Discovery, Published online: 16 September 2026; doi:10.1038/s41420-026-03345-y

rhNGF shows neuroprotective efficacy by counteracting oxidative stress and neuroinflammation in a glaucoma mouse model

Cell Death Discovery, Published online: 15 September 2026; doi:10.1038/s41420-026-03342-1

IFN-I induced-LAP3 promotes embryo resorption by inhibiting trophoblast mitophagy via targeting HSD17B10/PE pathway

Cell Death Discovery, Published online: 15 September 2026; doi:10.1038/s41420-026-03356-9

IL-6 trans-signaling suppresses amyloid-β production through an ADAM17-dependent positive feedback loop in Alzheimer’s disease

Cell Death Discovery, Published online: 14 September 2026; doi:10.1038/s41420-026-03312-7

Immunoregulatory role of quercetin in lung cancer

Cell Death Discovery, Published online: 14 September 2026; doi:10.1038/s41420-026-03328-z

HAT1 regulates glioblastoma cell proliferation and membrane lipid remodeling through ALDH2

Cell Death Discovery, Published online: 14 September 2026; doi:10.1038/s41420-026-03333-2

Hepatic Usp2 orchestrates de novo lipogenesis through G3bp2 stabilization and β-catenin activation

Cell Death Discovery, Published online: 11 September 2026; doi:10.1038/s41420-026-03338-x

Fibronectin 1 mediated histone lactylation promotes malignant progression of GIST regulated by m⁶A modification

Cell Death Discovery, Published online: 10 September 2026; doi:10.1038/s41420-026-03334-1

Metformin-mediated immunometabolic rewiring attenuates type I interferon-driven dendritic cell inflammation in STAT1 gain-of-function

Cell Death Discovery, Published online: 09 September 2026; doi:10.1038/s41420-026-03332-3

Multi-omic profiling reveals metabolic vulnerabilities in enzalutamide resistant prostate cancer

Cell Death Discovery, Published online: 09 September 2026; doi:10.1038/s41420-026-03340-3

Checkpoint kinase 2 deficiency affects the engagement of DNA double-strand break repair pathways following DNA damage

Cell Death Discovery, Published online: 09 September 2026; doi:10.1038/s41420-026-03337-y

Reorientation of the SUMOylation landscape and altered L3mbtl2-mediated transcriptional activity in cancer-associated muscle contractile dysfunction

Cell Death Discovery, Published online: 08 September 2026; doi:10.1038/s41420-026-03339-w

Lipotoxicity-induced ER-mitochondrial hypercoupling activates the mtDNA-cGAS-STING-NF-κB axis to drive follicular arrest in metabolically compromised PCOS

Cell Death Discovery, Published online: 07 September 2026; doi:10.1038/s41420-026-03299-1

G9a-mediated cholesterol metabolism triggers cuproptosis to promote alcohol-related liver disease

Cell Death Discovery, Published online: 03 September 2026; doi:10.1038/s41420-026-03327-0

Arrest of human spermatogenesis at the pachytene stage is frequently accompanied by disruption of the piRNA pathway

Cell Death Discovery, Published online: 01 September 2026; doi:10.1038/s41420-026-03316-3

Concurrent upregulation of autophagic flux and induction of the SQSTM1/p62-VCAM-1 axis deter radiosensitivity of triple-negative breast cancer cells

Cell Death Discovery, Published online: 01 September 2026; doi:10.1038/s41420-026-03324-3

MUC13 promotes cisplatin resistance in intrahepatic cholangiocarcinoma through regulation by histone H3K18 lactylation

Cell Death Discovery, Published online: 01 September 2026; doi:10.1038/s41420-026-03315-4

The insulin-like growth factor 2 mRNA-binding protein 2 affects tumor cell metabolism via mitochondrial transporter activity and lipid alterations

Cell Death Discovery, Published online: 31 August 2026; doi:10.1038/s41420-026-03306-5

Ibrutinib-triggered matriptase maintains extracellular CD19 and limits antigen escape in B-cell malignancy

Cell Death Discovery, Published online: 31 August 2026; doi:10.1038/s41420-026-03309-2

PLCE1 exacerbates the development of atherosclerosis by driving endothelial dysfunction and macrophage inflammation via targeting CTNNB1