Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10954-1

A specific population of macrophages that express high levels of the enzyme PLA2G2D in tumour-draining lymph nodes is associated with poor prognosis in patients, and inhibiting PLA2G2D improves anti-tumour immunity in mouse models.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10979-6

An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10998-3

TRI-611 induces the degradation of ALK fusion proteins via a previously undescribed CRBN recruitment motif, and its preclinical anti-tumour activity highlights TRI-611 as a potential new way of treating ALK-positive non-small-cell lung cancer.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10468-w

Eight integrated mutational footprints collectively explain the mutational processes in 85% of primary prostate cancer genomes.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10993-8

TM184C—an ancient G-protein-coupled receptor-like superdark protein involved in regulation of autophagy, intercellular connectivity and material exchange—underscores the promise of exploring the understudied human proteome and beyond.

Nature, Published online: 08 September 2026; doi:10.1038/d41586-026-02795-9

Limit bets on clinical-trial outcomes being placed on prediction markets

Nature, Published online: 21 May 2026; doi:10.1038/s41586-026-10656-8

De novo design of miniproteins targeting GPCRs

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10464-0

Researchers designed two-component proteins forming quasisymmetric cages via geometric frustration, enabling tunable virus-like assemblies for cargo delivery, cellular uptake and studying intracellular diffusion and protein localization.

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10297-x

A drawing-like task designed to study compositional generalization identifies a specific neural population in the ventral premotor cortex in primates that encodes action symbols.

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10571-y

The buffer pool designed to compensate for unintended carbon losses from the largest forest climate mitigation programme in the United States is too small when considering the impact of future climate change scenarios.

Nature, Published online: 19 May 2026; doi:10.1038/s41586-026-10652-y

A multi-agent system for automating scientific discovery

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10519-2

Author Correction: HER2 expression identifies dynamic functional states within circulating breast cancer cells

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10353-6

mRNA–lipid-nanoparticle vaccines do not require type 1 conventional dendritic (cDC1) cells or the WDFY4-dependent cross-presentation pathway for CD8+ T cell priming but, instead, engage both cDC1 and cDC2 cells redundantly.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10405-x

Evaluation by the Drug Rediscovery Protocol of off-label use of 37 approved cancer drugs on 1,610 patients showed modest activities overall, although subgroups of responders suggest that off-label drug use could be beneficial in tandem with more stringent biomarker selection.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10391-0

MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10344-7

Metastasis-associated oncofetal cell states emerge at the earliest stages of colorectal cancer and spatial profiling shows stereotypic patterning of fibroblast subtypes resembling normal tissue architecture, resulting in distinct regional microenvironments that dictate the timing and positioning of oncofetal plasticity.

Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00910-4

A system of protein binders directs energy-generating organelles to targeted cells, potentially improving ways to treat mitochondrial dysfunction.

Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00906-0

A large language model that is trained using AI outputs can inherit undesirable behaviours, even if they are not directly referenced in the training data.

Nature, Published online: 14 April 2026; doi:10.1038/s41586-026-10493-9

Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity

Nature, Published online: 10 April 2026; doi:10.1038/s41586-026-10484-w

Author Correction: Multi-omic profiling reveals age-related immune dynamics in healthy adults