Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10112-7

Genome-wide analysis shows European dogs existed by 14,200 years ago, were already genetically distinct, received less Neolithic Southwest Asian admixture than humans did and contributed substantially to later European dogs.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10270-8

Single-nucleus chromatin and RNA sequencing identifies epigenetic chromatin domains that confer vulnerability to paediatric brain tumours such as ependymomas, providing insight into the development of such tumours despite ‘quiet’ genomes.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10266-4

Insights into the mechanism by which phosphatidylserine functions as a non-classical inhibitory molecule during T cell exhaustion, and how phosphatidylserine-targeting antibodies enhance T cell responses are explored.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10255-7

Cas9 structures explain topology sensing and off-target activation.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10300-5

At present, only 13.4% of the global land surface meets the World Meteorological Organization requirements for annual precipitation monitoring.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10291-3

New evidence suggests that diffusive oxygen transport through the tracheolar–muscle system is not the limiting factor on insect body size.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10209-z

Ultrafast electron imaging shows full phase-space dynamics of optical singularities, which can reach superluminal velocities before annihilation and break the particle-like analogy of topological defects.