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AI-guided redesign of laboratory-evolved reverse transcriptases enhances prime editing

βœ‡Nature Biotechnology - Issue - nature.com science feeds
By: Y. Allen Tao Β· Holt A. Sakai Β· Allen Y. Jiang Β· Nicholas A. Krasnow Β· Vasilii S. Vaganov Β· Brian Shim Β· Zachary Barsdale Β· Smriti Pandey Β· Nouraiz Ahmed Β· Man Na Β· Ting-Wei Liao Β· Keyede Oye Β· Ana Cristian Β· Emily Zhang Β· Joy A. Xu Β· Mattijs Bulcaen Β· David R. Liu

Nature Biotechnology, Published online: 21 May 2026; doi:10.1038/s41587-026-03149-6

A computational redesign strategy improves evolved prime editors.
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Directed evolution of small RNA-stabilizing motifs that improve prime-editing efficiency

βœ‡Nature Biotechnology - Issue - nature.com science feeds
By: Holt A. Sakai Β· Sarah E. Pierce Β· Allen Y. Jiang Β· Ana Cristian Β· Meirui An Β· Chae Rin Kim Β· Nouraiz Ahmed Β· Colin F. Hemez Β· Y. Allen Tao Β· Emily Zhang Β· Sophia J. Wu Β· David R. Liu

Nature Biotechnology, Published online: 20 May 2026; doi:10.1038/s41587-026-03123-2

Prime editing is improved with engineered RNA-stabilizing motifs.
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