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In vivo endosomal escape assay identifies mechanisms for efficient hepatic LNP delivery

Nature Biotechnology - Issue - nature.com science feeds

By: Antony Jozić · Chloé Le Roux · Jeonghwan Kim · Mathieu Berchel · Deepak Kumar Sahel · Emily K. Bodi · Michelle Palumbo · Aishwarya Vasudevan · Namratha Turuvekere Vittala Murthy · Yulia Eygeris · Milan Gautam · Elissa Bloom · Anthony P. Barnes · Paul-Alain Jaffrès · Gaurav Sahay

11 March 2026 at 08:00

Nature Biotechnology, Published online: 11 March 2026; doi:10.1038/s41587-026-03022-6

Endosomal escape of lipid nanoparticles is quantified and optimized in vivo.