Oncogene, Published online: 04 October 2026; doi:10.1038/s41388-026-04002-5
KDM4A drives TGCT metastasis by inducing focal adhesion disassembly via STAT1-mediated CCL3 transcriptional activation
Oncogene, Published online: 02 October 2026; doi:10.1038/s41388-026-03990-8
Colorectal cancer is often treated with oxaliplatin, but many tumors become less responsive over time, making treatment harder. This study aimed to understand one way cancer cells escape oxaliplatin and to identify a possible way to restore drug response. The researchers studied colorectal cancer cells, drug-resistant cells, mouse tumor models, and tumor-like structures grown from patient samples. They found that oxaliplatin stress lowers a mitochondrial protein called TFAM. This allows mitochondrial DNA to leak into the cell fluid and switch on a survival signal involving TBK1. This signal helps cancer cells clear damaged cell parts and survive treatment. Blocking TBK1 reduced this protective response and made resistant tumors more sensitive to oxaliplatin. These findings suggest that combining oxaliplatin with a TBK1-blocking treatment may help overcome drug resistance in colorectal cancer in the future.
Oncogene, Published online: 01 October 2026; doi:10.1038/s41388-026-04001-6
Nuclear cathepsin L induces DNA damage by regulating DNA repair factors in ovarian cancer
Oncogene, Published online: 30 September 2026; doi:10.1038/s41388-026-03995-3
ACTB promotes ESCC progression by regulating the AKT–mTOR signaling pathway through an m6A-dependent mechanism
Oncogene, Published online: 28 September 2026; doi:10.1038/s41388-026-03996-2
SPTLC2-driven sphingolipid reprogramming of neutrophils impairs anti-tumour immunity and drives liver cancer progression
Oncogene, Published online: 27 September 2026; doi:10.1038/s41388-026-03930-6
Metabolites and cancer metastasis
Oncogene, Published online: 25 September 2026; doi:10.1038/s41388-026-03992-6
A positive feedback loop between YTHDC1 and EP300 drives multiple myeloma tumorigenesis
Oncogene, Published online: 25 September 2026; doi:10.1038/s41388-026-03998-0
KIFC1 engages RUNX2/TGF-β signaling to promote lung cancer bone metastasis via disrupting bone homeostasis
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