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Effects of daily multivitamin–multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial

By: Sidong Li · Rikuta Hamaya · Haidong Zhu · Brian H. Chen · Alexandre C. Pereira · Kerry L. Ivey · Pamela M. Rist · JoAnn E. Manson · Yanbin Dong · Howard D. Sesso

9 March 2026 at 08:00

Nature Medicine, Published online: 09 March 2026; doi:10.1038/s41591-026-04239-3

In a prespecified ancillary analysis of the COSMOS randomized trial, supplementation with daily multivitamins, but not with cocoa extract, over the course of 2 years decreased biological aging, as measured by epigenetic aging clocks.