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A deep joint-learning proteomics model for diagnosis of six conditions associated with dementia

By: Lijun An · Alexa Pichet Binette · Ines Hristovska · Gabriele Vilkaite · Yu Xiao · Romina Zendehdel · Zijian Dong · Bart Smets · Rowan Saloner · Shinya Tasaki · Ying Xu · Varsha Krish · Farhad Imam · Shorena Janelidze · Danielle van Westen · Erik Stomrud · Christopher D. Whelan · Sebastian Palmqvist · Rik Ossenkoppele · Niklas Mattsson-Carlgren · Oskar Hansson · Jacob W. Vogel

31 March 2026 at 08:00

Nature Medicine, Published online: 31 March 2026; doi:10.1038/s41591-026-04303-y

ProtAIDe-Dx is a deep joint-learning model that uses plasma proteomics to provide simultaneous probabilistic diagnoses across six conditions associated with aging.

Blood phosphorylated tau elevation as a biomarker in immunoglobulin light chain and transthyretin amyloidosis

Nature Medicine

By: Stephan A. Kaeser · Stephanie A. Schultz · Anna Hofmann · Lisa M. Häsler · Ying Xu · Marius Lambert · Ulrike Obermüller · Kathrin Brockmann · Johan Bijzet · Hans Nienhuis · Mario Nuvolone · Laura Obici · Giovanni Palladini · Ute Hegenbart · Stefan O. Schönland · Mathias Jucker

11 March 2026 at 08:00

Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04272-2

Elevated serum levels of phosphorylated tau are not specific to Alzheimer’s disease and may also serve as a diagnostic tool for the most common types of systemic amyloidosis, with potential utility in distinguishing amyloidosis-related polyneuropathy from polyneuropathy of other etiologies.