Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04256-2

Whole-genome phylogenetic analyses have identified a case of monkeypox virus clade IIb lineage in the Republic of the Congo and co-circulation of three clade lineages, emphasizing the importance of improved surveillance given the risk of possible recombination events in the future.

Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04302-z

Exposome analyses across 34 countries showed that social exposures were associated with faster functional brain aging and physical exposures with faster structural brain aging.

Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04305-w

To accelerate therapeutic development and equip stakeholders with clear benchmarks, the authors outline target product profiles for therapies designed to delay or prevent the onset of clinical symptoms of Alzheimer’s disease.

Nature Medicine, Published online: 02 April 2026; doi:10.1038/s41591-026-04379-6

Author Correction: Real-world clinical utility of tumor whole-genome sequencing in solid cancers

Nature Medicine, Published online: 02 April 2026; doi:10.1038/s41591-026-04320-x

Quality health information for all is a fundamental determinant of health

Nature Medicine, Published online: 02 April 2026; doi:10.1038/s41591-026-04281-1

A prespecified analysis from the SELECT trial showed that semaglutide reduces major adverse cardiovascular events by 20% compared with placebo, particularly in patients at high risk of fibrosis, as indicated by the Fibrosis-4 index.

Nature Medicine, Published online: 01 April 2026; doi:10.1038/d41591-026-00019-1

After decades of stagnation, a renewed push in tuberculosis research is expanding the drug and vaccine pipeline to bring one of humanity’s oldest and deadliest infectious diseases under control.

Nature Medicine, Published online: 31 March 2026; doi:10.1038/s41591-026-04322-9

Nourishing people demands collaboration across sectors, political cycles and countries.

Nature Medicine, Published online: 31 March 2026; doi:10.1038/d41591-026-00018-2

In the phase 3 EVOKE(+) trials, semaglutide did not slow clinical progression of Alzheimer’s disease, but the findings provide new insights in the ongoing quest for treatments.

Nature Medicine, Published online: 31 March 2026; doi:10.1038/s41591-026-04303-y

ProtAIDe-Dx is a deep joint-learning model that uses plasma proteomics to provide simultaneous probabilistic diagnoses across six conditions associated with aging.

Nature Medicine, Published online: 31 March 2026; doi:10.1038/s41591-026-04315-8

Benralizumab (an anti-IL-5 receptor α antibody), compared to placebo, significantly reduced the risk of first flare in patients with hypereosinophilic syndrome.

Nature Medicine, Published online: 30 March 2026; doi:10.1038/s41591-026-04286-w

We have systematically mapped the exposome onto health and disease risk to replace pervasive fragmented research. Although exposure associations are modest, these reproducible patterns reflect how our surroundings can affect our bodies and collectively shape our health. Our atlas provides a blueprint for integrating and evaluating environmental factors into precision medicine.

Nature Medicine, Published online: 30 March 2026; doi:10.1038/s41591-026-04321-w

Despite major global declines in ischemic heart disease mortality, the influence of suboptimal diet remains substantial and unevenly distributed across populations. This study quantifies the contributions of individual dietary components to ischemic heart disease over more than 30 years and uncovers persistent disparities by age, sex, region and socioeconomic status.

Nature Medicine, Published online: 30 March 2026; doi:10.1038/s41591-026-04259-z

Genetic sequencing data from a large cohort of Latin American individuals showed that the genes that are significantly associated with the risk of autism extensively overlapped with those found in genome-wide sequencing studies in people of predominantly European ancestry.

Nature Medicine, Published online: 25 March 2026; doi:10.1038/s41591-026-04296-8

Early clinical data on in vivo CAR-T cell therapy for multiple myeloma reveals key mechanistic insights and could mark the beginning of a new era of fast, streamlined and accessible immunotherapies.

Nature Medicine, Published online: 25 March 2026; doi:10.1038/s41591-025-04115-6

A blueprint to accelerate rare pediatric gene therapy approvals

Nature Medicine, Published online: 25 March 2026; doi:10.1038/s41591-026-04244-6

In a phase 1 trial, the in vivo generation of anti-BCMA CAR-T cells by lentiviral delivery was feasible and did not lead to dose-limiting toxicities in five patients with relapsed or refractory multiple myeloma.

Nature Medicine, Published online: 25 March 2026; doi:10.1038/s41591-026-04299-5

Results of the phase 2 POLAR trial show that biomarker-guided treatment in patients with metastatic pancreatic cancer based on homologous repair deficiency leads to encouraging clinical response rates in immune cell-infiltrated tumors.

Nature Medicine, Published online: 24 March 2026; doi:10.1038/s41591-026-04298-6

Local control, remote expertise: governing therapeutic telemedicine in wartime

Nature Medicine, Published online: 24 March 2026; doi:10.1038/d41591-026-00016-4

The small molecule rezatapopt binds a unique pocket in Y220C-mutant p53 and restores its tumor-suppressor function; a phase 1 study provides proof of concept of this therapeutic approach.