Nature Medicine, Published online: 01 April 2026; doi:10.1038/d41591-026-00019-1

After decades of stagnation, a renewed push in tuberculosis research is expanding the drug and vaccine pipeline to bring one of humanity’s oldest and deadliest infectious diseases under control.

Nature Medicine, Published online: 31 March 2026; doi:10.1038/s41591-026-04322-9

Nourishing people demands collaboration across sectors, political cycles and countries.

Nature Medicine, Published online: 31 March 2026; doi:10.1038/d41591-026-00018-2

In the phase 3 EVOKE(+) trials, semaglutide did not slow clinical progression of Alzheimer’s disease, but the findings provide new insights in the ongoing quest for treatments.

Nature Medicine, Published online: 31 March 2026; doi:10.1038/s41591-026-04303-y

ProtAIDe-Dx is a deep joint-learning model that uses plasma proteomics to provide simultaneous probabilistic diagnoses across six conditions associated with aging.

Nature Medicine, Published online: 31 March 2026; doi:10.1038/s41591-026-04315-8

Benralizumab (an anti-IL-5 receptor α antibody), compared to placebo, significantly reduced the risk of first flare in patients with hypereosinophilic syndrome.

Nature Medicine, Published online: 30 March 2026; doi:10.1038/s41591-026-04286-w

We have systematically mapped the exposome onto health and disease risk to replace pervasive fragmented research. Although exposure associations are modest, these reproducible patterns reflect how our surroundings can affect our bodies and collectively shape our health. Our atlas provides a blueprint for integrating and evaluating environmental factors into precision medicine.

Nature Medicine, Published online: 30 March 2026; doi:10.1038/s41591-026-04321-w

Despite major global declines in ischemic heart disease mortality, the influence of suboptimal diet remains substantial and unevenly distributed across populations. This study quantifies the contributions of individual dietary components to ischemic heart disease over more than 30 years and uncovers persistent disparities by age, sex, region and socioeconomic status.

Nature Medicine, Published online: 30 March 2026; doi:10.1038/s41591-026-04259-z

Genetic sequencing data from a large cohort of Latin American individuals showed that the genes that are significantly associated with the risk of autism extensively overlapped with those found in genome-wide sequencing studies in people of predominantly European ancestry.