Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04678-y
Author Correction: Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance
Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04647-5
Consensus framework for the validation of generative AI: call for collaborators on the Validation Accords
Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04685-z
As the availability of clinical trial data continues to lag behind, other forms of evidence generation leveraging real-world data and citizen science need to be considered to improve women’s health.
Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04607-z
Following preclinical development, a randomized first-in-human trial showed that treatment with an inhaled, lung-epithelium-targeted siRNA directed against the receptor for advanced glycation end-products (RAGE) was safe and well tolerated and reduced RAGE levels in serum and bronchoalveolar lavage fluid.
Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04615-z
In a phase 2 randomized clinical trial, treatment with the myeloperoxidase (MPO) inhibitor mitiperstat, intended to target the neutrophil–MPO inflammatory pathway, did not improve symptoms or exercise function in individuals with heart failure with preserved or mildly reduced ejection fraction.
Nature Medicine, Published online: 08 September 2026; doi:10.1038/s41591-026-04641-x
A binding ban, and its limits: Japan legislates on heritable human genome editing
Nature Medicine, Published online: 07 September 2026; doi:10.1038/s41591-026-04633-x
The first generation of medical artificial intelligence (AI) was judged on whether algorithms could match clinicians. The next generation should be judged on whether carefully designed human–AI systems can improve patient outcomes.
Nature Medicine, Published online: 07 September 2026; doi:10.1038/s41591-026-04645-7
Strengthening clinical trial ethics and regulatory oversight in Africa: lessons from the TRACE initiative
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