arXiv:2609.10108v1 Announce Type: cross Abstract: Aging clocks quantify biological aging and help characterize individual health status. What protein interactions are important for accurate aging clocks, and are they zeroth-order or higher-order? Addressing these questions requires learning from large molecular datasets distributed across medical centers, where privacy constraints prevent centralized data sharing. Federated learning offers a natural solution but faces four challenges in this setting: limited local sample sizes, sparse and directional inter-center trust, the need to retain discriminative age prediction while supporting interpretation, and model drift and forgetting under heterogeneous cross-center data. We propose TNFL, a trust-network-based federated learning framework that progressively propagates models along directed pairwise trust relations without centralized aggregation. TNFL combines an age-aware mixture-of-experts model with generative replay to preserve previously learned information and reduce forgetting and drift. Experiments across multiple molecular datasets show that TNFL enables effective aging-clock prediction with limited local data, provides interpretable age-dependent prediction patterns, and maintains stable performance across interaction orders. To investigate the biological questions, we analyze TNFL-identified pairwise protein interactions and their higher-order organization through functional and network analyses. The identified interactions repeatedly form coordinated higher-order subnetworks spanning multiple aging-related biological systems, with several proteins recurring across subnetworks. These findings suggest that TNFL captures molecular relationships beyond isolated pairwise associations and reveals coherent higher-order biological organization associated with aging.

arXiv:2605.24636v2 Announce Type: new Abstract: While large language models (LLMs) hold transformative potential for medicine, their reasoning robustness and safety in real-world clinical scenarios remain critically underexplored, particularly in dentistry. Here we introduce GlobalDentBench, the first multinational dental benchmark, featuring a taxonomy that encompasses 14 dental specialties across 88 countries and regions spanning six continents. The benchmark comprises 8,978 expert-validated questions across three formats (multiple-choice, short-answer, and case-based questions) and assesses three progressive reasoning levels: knowledge recall (L1), routine reasoning (L2), and individualized reasoning (L3). To ensure data quality, the automated construction framework was calibrated by six senior dentists, achieving expert agreement rates of 99.98% for multiple-choice and short-answer questions and 96.78% for the more complex case-based questions. Evaluation of 12 frontier LLMs on GlobalDentBench revealed a sharp, stepwise performance degradation with increasing reasoning complexity. Specifically, accuracy plummeted from 81.34% on multiple-choice to 64.53% on short-answer and 22.34% on case-based questions, while declining markedly from 74.01% at L1 to 55.64% at L2 and 35.71% at L3. More critically, risk analysis of real-world dental cases demonstrated an alarming overall unsafe rate of 31.01% in LLM-generated clinical recommendations, with 4.51% posing risks of irreversible patient harm and risks particularly pronounced in specialties such as orthodontics. These findings expose fundamental limitations in the medical reasoning and safety of current LLMs. Consequently, GlobalDentBench provides a scalable foundation for trustworthy clinical AI evaluation, underscoring the urgent need for rigorous validation before the safe deployment of these models in healthcare.

arXiv:2605.24326v1 Announce Type: cross Abstract: The rapid scaling of large language model training requires distributing GPU resources across multiple data center buildings and regions. We refer to such paradigm as "scale-across" training. As infrastructure expands, the system design space becomes increasingly intricate, encompassing new model architectures, hardware heterogeneity, and evolving communication patterns. Drawing from Meta's production experience, we highlight the complexities of deploying training jobs across a few data centers housing hundreds of thousands of GPUs. To accelerate exploration of the large design space and to enable efficient training for frontier model development, we conduct in-depth characterization of three key design dimensions: parallelism placement, parallelism scheduling, and network layer technologies. We then propose ScaleAcross Explorer, an optimizer that considers the interplay of design dimensions and holistically optimizes scale-across training. Testbed experiments and simulations demonstrate up to 64.62% training speedups over production configuration and up to 37.59% training speedups over the state-of-the-art baseline across a wide range of design points.

arXiv:2604.02369v2 Announce Type: replace-cross Abstract: Agent communication protocols are becoming critical infrastructure for large language model (LLM) systems that must use tools, coordinate with other agents, and operate across heterogeneous environments. This work presents a human-inspired perspective on this emerging landscape by organizing agent communication into three layers: communication, syntactic, and semantic. Under this framework, we systematically analyze 18 representative protocols and compare how they support reliable transport, structured interaction, and meaning-level coordination. Our analysis shows a clear imbalance in current protocol design. Most protocols provide increasingly mature support for transport, streaming, schema definition, and lifecycle management, but offer limited protocol-level mechanisms for clarification, context alignment, and verification. As a result, semantic responsibilities are often pushed into prompts, wrappers, or application-specific orchestration logic, creating hidden interoperability and maintenance costs. To make this gap actionable, we further identify major forms of technical debt in today's protocol ecosystem and distill practical guidance for selecting protocols under different deployment settings. We conclude by outlining a research agenda for interoperable, secure, and semantically robust agent ecosystems that move beyond message passing toward shared understanding.

arXiv:2604.01600v1 Announce Type: new Abstract: Multimodal Large Language Models (MLLMs) have recently demonstrated promising capabilities in multimodal coding tasks such as chart-to-code generation. However, existing methods primarily rely on supervised fine-tuning (SFT), which requires the model to learn code patterns through chart-code pairs but does not expose the model to a code execution environment. Moreover, while self-correction through execution feedback offers a potential route to improve coding quality, even state-of-the-art MLLMs have been shown to struggle with effective self-correction. In this work, we introduce MM-ReCoder, a chart-to-code generation model trained with reinforcement learning (RL) and equipped with self-correction ability. We propose a two-stage multi-turn self-correction RL strategy based on Group Relative Policy Optimization (GRPO). The first stage enhances the model's self-correction ability via rolling out a shared first turn, while the second stage improves the coding capability with full-trajectory optimization. MM-ReCoder learns to produce more accurate and executable code through the interaction with the environment and by iteratively correcting its own outputs. Our results on three chart-to-code benchmarks demonstrate the state-of-the-art performance of MM-ReCoder.

arXiv:2512.21106v2 Announce Type: replace-cross Abstract: Graph-structured data exhibit substantial heterogeneity in where their predictive signals originate: in some domains, node-level semantics dominate, while in others, structural patterns play a central role. This structure-semantics heterogeneity implies that no graph learning model with a fixed inductive bias can generalize optimally across diverse graph domains. However, most existing methods address this challenge from the model side by incrementally injecting new inductive biases, which remains fundamentally limited given the open-ended diversity of real-world graphs. In this work, we take a data-centric perspective and treat node semantics as a task-adaptive variable. We propose a Graph-Exemplar-guided Semantic Refinement (GES) framework for graph representation learning which -- unlike existing LLM-enhanced methods that generate node descriptions without graph context -- leverages structurally and semantically similar nodes from the graph itself to guide semantic refinement. Specifically, a GNN is first trained to produce predictive states, which along with structural and semantic similarity are used to retrieve in-graph exemplars that inform an LLM in refining node descriptions. We evaluate our approach on both text-rich and text-free graphs. Results show consistent improvements on semantics-rich and structure-dominated graphs, demonstrating the effectiveness of data-centric semantic refinement under structure-semantics heterogeneity.

arXiv:2603.22943v1 Announce Type: new Abstract: Personalized text-to-image generation lets users fine-tune diffusion models into repositories of concept-specific checkpoints, but serving these repositories efficiently is difficult for two reasons: natural-language requests are often ambiguous and can be misrouted to visually similar checkpoints, and standard post-training quantization can distort the fragile representations that encode personalized concepts. We present PersonalQ, a unified framework that connects checkpoint selection and quantization through a shared signal -- the checkpoint's trigger token. Check-in performs intent-aligned selection by combining intent-aware hybrid retrieval with LLM-based reranking over checkpoint context and asks a brief clarification question only when multiple intents remain plausible; it then rewrites the prompt by inserting the selected checkpoint's canonical trigger. Complementing this, Trigger-Aware Quantization (TAQ) applies trigger-aware mixed precision in cross-attention, preserving trigger-conditioned key/value rows (and their attention weights) while aggressively quantizing the remaining pathways for memory-efficient inference. Experiments show that PersonalQ improves intent alignment over retrieval and reranking baselines, while TAQ consistently offers a stronger compression-quality trade-off than prior diffusion PTQ methods, enabling scalable serving of personalized checkpoints without sacrificing fidelity.

arXiv:2603.12719v1 Announce Type: cross Abstract: Point cloud registration (PCR) is a fundamental task in 3D vision and provides essential support for applications such as autonomous driving, robotics, and environmental modeling. Despite its widespread use, existing methods often fail when facing real-world challenges like heavy noise, significant occlusions, and large-scale transformations. These limitations frequently result in compromised registration accuracy and insufficient robustness in complex environments. In this paper, we propose IGASA as a novel registration framework constructed upon a Hierarchical Pyramid Architecture (HPA) designed for robust multi-scale feature extraction and fusion. The framework integrates two pivotal components consisting of the Hierarchical Cross-Layer Attention (HCLA) module and the Iterative Geometry-Aware Refinement (IGAR) module. The HCLA module utilizes skip attention mechanisms to align multi-resolution features and enhance local geometric consistency. Simultaneously, the IGAR module is designed for the fine matching phase by leveraging reliable correspondences established during coarse matching. This synergistic integration within the architecture allows IGASA to adapt effectively to diverse point cloud structures and intricate transformations. We evaluate the performance of IGASA on four widely recognized benchmark datasets including 3D(Lo)Match, KITTI, and nuScenes. Our extensive experiments consistently demonstrate that IGASA significantly surpasses state-of-the-art methods and achieves notable improvements in registration accuracy. This work provides a robust foundation for advancing point cloud registration techniques while offering valuable insights for practical 3D vision applications. The code for IGASA is available in \href{https://github.com/DongXu-Zhang/IGASA}{https://github.com/DongXu-Zhang/IGASA}.

arXiv:2603.12721v1 Announce Type: cross Abstract: Robust point cloud registration is a fundamental task in 3D computer vision and geometric deep learning, essential for applications such as large-scale 3D reconstruction, augmented reality, and scene understanding. However, the performance of established learning-based methods often degrades in complex, real world scenarios characterized by incomplete data, sensor noise, and low overlap regions. To address these limitations, we propose CMHANet, a novel Cross-Modal Hybrid Attention Network. Our method integrates the fusion of rich contextual information from 2D images with the geometric detail of 3D point clouds, yielding a comprehensive and resilient feature representation. Furthermore, we introduce an innovative optimization function based on contrastive learning, which enforces geometric consistency and significantly improves the model's robustness to noise and partial observations. We evaluated CMHANet on the 3DMatch and the challenging 3DLoMatch datasets. \rev{Additionally, zero-shot evaluations on the TUM RGB-D SLAM dataset verify the model's generalization capability to unseen domains.} The experimental results demonstrate that our method achieves substantial improvements in both registration accuracy and overall robustness, outperforming current techniques. We also release our code in \href{https://github.com/DongXu-Zhang/CMHANet}{https://github.com/DongXu-Zhang/CMHANet}.

arXiv:2510.14686v2 Announce Type: replace-cross Abstract: We introduce xLLM, an intelligent and efficient Large Language Model (LLM) inference framework designed for high-performance, large-scale enterprise-grade serving, with deep optimizations for diverse AI accelerators. To address these challenges, xLLM builds a novel decoupled service-engine architecture. At the service layer, xLLM-Service features an intelligent scheduling module that efficiently processes multimodal requests and co-locates online and offline tasks through unified elastic scheduling to maximize cluster utilization. This module also relies on a workload-adaptive dynamic Prefill-Decode (PD) disaggregation policy and a novel Encode-Prefill-Decode (EPD) disaggregation policy designed for multimodal inputs. Furthermore, it incorporates a distributed architecture to provide global KV Cache management and robust fault-tolerant capabilities for high availability. At the engine layer, xLLM-Engine co-optimizes system and algorithm designs to fully saturate computing resources. This is achieved through comprehensive multi-layer execution pipeline optimizations, an adaptive graph mode and an xTensor memory management. xLLM-Engine also further integrates algorithmic enhancements such as optimized speculative decoding and dynamic EPLB, collectively serving to substantially boost throughput and inference efficiency. Extensive evaluations demonstrate that xLLM delivers significantly superior performance and resource efficiency. Under identical TPOT constraints, xLLM achieves throughput up to 1.7x that of MindIE and 2.2x that of vLLM-Ascend with Qwen-series models, while maintaining an average throughput of 1.7x that of MindIE with Deepseek-series models. xLLM framework is publicly available at https://github.com/jd-opensource/xllm and https://github.com/jd-opensource/xllm-service.

arXiv:2602.19969v1 Announce Type: cross Abstract: The strong capabilities of recent Large Language Models (LLMs) have made them highly effective for zero-shot re-ranking task. Attention-based re-ranking methods, which derive relevance scores directly from attention weights, offer an efficient and interpretable alternative to generation-based re-ranking methods. However, they still face two major limitations. First, attention signals are highly concentrated a small subset of tokens within a few documents, making others indistinguishable. Second, attention often overemphasizes phrases lexically similar to the query, yielding biased rankings that irrelevant documents with mere lexical resemblance are regarded as relevant. In this paper, we propose \textbf{ReAttn}, a post-hoc re-weighting strategy for attention-based re-ranking methods. It first compute the cross-document IDF weighting to down-weight attention on query-overlapping tokens that frequently appear across the candidate documents, reducing lexical bias and emphasizing distinctive terms. It then employs entropy-based regularization to mitigate over-concentrated attention, encouraging a more balanced distribution across informative tokens. Both adjustments operate directly on existing attention weights without additional training or supervision. Extensive experiments demonstrate the effectiveness of our method.

arXiv:2602.20019v1 Announce Type: cross Abstract: Dynamic graph anomaly detection (DGAD) is critical for many real-world applications but remains challenging due to the scarcity of labeled anomalies. Existing methods are either unsupervised or semi-supervised: unsupervised methods avoid the need for labeled anomalies but often produce ambiguous boundary, whereas semi-supervised methods can overfit to the limited labeled anomalies and generalize poorly to unseen anomalies. To address this gap, we consider a largely underexplored problem in DGAD: learning a discriminative boundary from normal/unlabeled data, while leveraging limited labeled anomalies \textbf{when available} without sacrificing generalization to unseen anomalies. To this end, we propose an effective, generalizable, and model-agnostic framework with three main components: (i) residual representation encoding that capture deviations between current interactions and their historical context, providing anomaly-relevant signals; (ii) a restriction loss that constrain the normal representations within an interval bounded by two co-centered hyperspheres, ensuring consistent scales while keeping anomalies separable; (iii) a bi-boundary optimization strategy that learns a discriminative and robust boundary using the normal log-likelihood distribution modeled by a normalizing flow. Extensive experiments demonstrate the superiority of our framework across diverse evaluation settings.

arXiv:2602.14602v1 Announce Type: cross Abstract: The opioid epidemic continues to ravage communities worldwide, straining healthcare systems, disrupting families, and demanding urgent computational solutions. To combat this lethal opioid crisis, graph learning methods have emerged as a promising paradigm for modeling complex drug-related phenomena. However, a significant gap remains: there is no comprehensive benchmark for systematically evaluating these methods across real-world opioid crisis scenarios. To bridge this gap, we introduce OPBench, the first comprehensive opioid benchmark comprising five datasets across three critical application domains: opioid overdose detection from healthcare claims, illicit drug trafficking detection from digital platforms, and drug misuse prediction from dietary patterns. Specifically, OPBench incorporates diverse graph structures, including heterogeneous graphs and hypergraphs, to preserve the rich and complex relational information among drug-related data. To address data scarcity, we collaborate with domain experts and authoritative institutions to curate and annotate datasets while adhering to privacy and ethical guidelines. Furthermore, we establish a unified evaluation framework with standardized protocols, predefined data splits, and reproducible baselines to facilitate fair and systematic comparison among graph learning methods. Through extensive experiments, we analyze the strengths and limitations of existing graph learning methods, thereby providing actionable insights for future research in combating the opioid crisis. Our source code and datasets are available at https://github.com/Tianyi-Billy-Ma/OPBench.

arXiv:2602.14919v1 Announce Type: cross Abstract: Hypergraph Neural Networks (HyGNNs) have demonstrated remarkable success in modeling higher-order relationships among entities. However, their performance often degrades on heterophilic hypergraphs, where nodes connected by the same hyperedge tend to have dissimilar semantic representations or belong to different classes. While several HyGNNs, including our prior work BHyGNN, have been proposed to address heterophily, their reliance on labeled data significantly limits their applicability in real-world scenarios where annotations are scarce or costly. To overcome this limitation, we introduce BHyGNN+, a self-supervised learning framework that extends BHyGNN for representation learning on heterophilic hypergraphs without requiring ground-truth labels. The core idea of BHyGNN+ is hypergraph duality, a structural transformation where the roles of nodes and hyperedges are interchanged. By contrasting augmented views of a hypergraph against its dual using cosine similarity, our framework captures essential structural patterns in a fully unsupervised manner. Notably, this duality-based formulation eliminates the need for negative samples, a common requirement in existing hypergraph contrastive learning methods that is often difficult to satisfy in practice. Extensive experiments on eleven benchmark datasets demonstrate that BHyGNN+ consistently outperforms state-of-the-art supervised and self-supervised baselines on both heterophilic and homophilic hypergraphs. Our results validate the effectiveness of leveraging hypergraph duality for self-supervised learning and establish a new paradigm for representation learning on challenging, unlabeled hypergraphs.