Nature Biomedical Engineering, Published online: 06 October 2026; doi:10.1038/s41551-026-01786-5

A nanoscale metal–organic framework (MOF)-based cancer vaccine platform enables coordinated antigen presentation and innate immune activation, resulting in tumour regression, immune memory and protection against metastasis.

Nature Biomedical Engineering, Published online: 06 October 2026; doi:10.1038/s41551-026-01780-x

A long-term flexible electrode array system stably tracks individual neurons for months, revealing intrinsic drift in visual evoked neural activity and potentiating durable cross-session and cross-animal decoding.

Nature Biomedical Engineering, Published online: 05 October 2026; doi:10.1038/s41551-026-01805-5

This Review highlights how organoids and organ-on-a-chip technologies are transforming gastrointestinal disease research by providing clinically relevant models of inflammation, infection and cancer and discusses future opportunities for therapeutic developments.

Nature Biomedical Engineering, Published online: 05 October 2026; doi:10.1038/s41551-026-01806-4

Multi-organ-on-a-chip systems aim to improve the prediction of human drug responses by replicating organ interactions in vitro. This Review discusses advances in niche-preserving engineering, scalable manufacturing and multimodal readouts needed to make these systems reliable tools.

Nature Biomedical Engineering, Published online: 05 October 2026; doi:10.1038/s41551-026-01798-1

A positron emission tomography tracer that directly targets bacterial metabolism by exploiting the phosphotransferase system, a carbohydrate transport pathway absent in mammalian cells, enables selective detection of living bacteria in vivo.

Nature Biomedical Engineering, Published online: 28 September 2026; doi:10.1038/s41551-026-01815-3

Author Correction: Intermittent hypobaric pressure induces selective senescent cell death and alleviates age-related osteoporosis

Nature Biomedical Engineering, Published online: 23 September 2026; doi:10.1038/s41551-026-01791-8

Unsaturated phospholipids unexpectedly form multilamellar, multivesicular liposomes that efficiently encapsulate hydrophilic drugs and suppress burst release. These structures enable ultra-slow drug release and produce weeks-long sciatic nerve block with tetrodotoxin in rats.

Nature Biomedical Engineering, Published online: 23 September 2026; doi:10.1038/s41551-026-01793-6

Contrary to expectations that unsaturation accelerates release, unsaturated phospholipid liposomes showed 3-fold higher loading and markedly reduced initial and sustained release due to multilamellar–multivesicular structure.

Nature Biomedical Engineering, Published online: 11 September 2026; doi:10.1038/s41551-026-01789-2

Advances in three-dimensional endometrial in vitro models are providing physiologically relevant systems to investigate embryo implantation, tissue remodelling and reproductive disorders, expanding our toolbox for supporting women’s health.

Nature Biomedical Engineering, Published online: 11 September 2026; doi:10.1038/s41551-026-01787-4

Applying extensive chemical modifications to RNA motifs substantially enhances prime editing efficiency in vivo and can be applied for improved efficiencies across RNA-based editing systems.

Nature Biomedical Engineering, Published online: 10 September 2026; doi:10.1038/s41551-026-01810-8

Author Correction: Radiotherapy-triggered reduction of platinum-based chemotherapeutic prodrugs in tumours

Nature Biomedical Engineering, Published online: 09 September 2026; doi:10.1038/s41551-026-01792-7

Generative artificial intelligence (AI) has revolutionized protein engineering and has enabled de novo design of protein binders against dozens of target antigens. Our study combines AI-assisted binder design, binder integration into chimaeric antigen receptor (CAR) constructs and scalable in vitro and in vivo cell models to infer amino acid sequences and protein structures of designed binders that might facilitate efficacious CAR T cell therapies.

Nature Biomedical Engineering, Published online: 09 September 2026; doi:10.1038/s41551-026-01790-9

A generative protein design workflow addresses important challenges with de novo protein engineering of chimaeric antigen receptors (CARs) to improve targeting of proteins important in cancer and create more effective CAR T therapies.

Nature Biomedical Engineering, Published online: 07 September 2026; doi:10.1038/s41551-026-01794-5

Author Correction: A base editor for the long-term restoration of auditory function in mice with recessive profound deafness

Nature Biomedical Engineering, Published online: 31 August 2026; doi:10.1038/s41551-026-01782-9

A protein engineering strategy enables nitric oxide-triggered reactivation of proteins using genetically encoded caged amino acids, allowing inflammation-localized control of protein activity, viral gene delivery and biosensing in vivo.

Nature Biomedical Engineering, Published online: 31 August 2026; doi:10.1038/s41551-026-01779-4

This large-scale study of white matter structural connectivity during development reveals biomarkers associated with attention deficit hyperactivity disorder in youth that track symptom trajectories and predict differential treatment response.

Nature Biomedical Engineering, Published online: 28 August 2026; doi:10.1038/s41551-026-01785-6

This Perspective argues that biological discovery and drug development should be linked in a continuous data feedback loop that iteratively refines therapeutic hypotheses, drug design and patient stratification across discovery and clinical stages.

Nature Biomedical Engineering, Published online: 26 August 2026; doi:10.1038/s41551-026-01766-9

We present a multiple-instance learning framework that aggregates patch-level features into reliable slide-level predictions through the use of random sampling at both patch and feature levels. Our approach enables large-batch optimization and consistent performance gains across 35 clinical tasks and 4 foundation models, and supports principled uncertainty estimation for every slide-level prediction.

Nature Biomedical Engineering, Published online: 26 August 2026; doi:10.1038/s41551-026-01774-9

Autophagy receptors are engineered fusing LC3 to cytoplasm-stable antibody variants and are delivered via small extracellular vesicles or adeno-associated virus to eliminate pathological Tau and TDP-43 in animal disease models.