Nature Biomedical Engineering, Published online: 06 October 2026; doi:10.1038/s41551-026-01786-5

A nanoscale metal–organic framework (MOF)-based cancer vaccine platform enables coordinated antigen presentation and innate immune activation, resulting in tumour regression, immune memory and protection against metastasis.

Nature Biomedical Engineering, Published online: 06 October 2026; doi:10.1038/s41551-026-01780-x

A long-term flexible electrode array system stably tracks individual neurons for months, revealing intrinsic drift in visual evoked neural activity and potentiating durable cross-session and cross-animal decoding.

Nature Biomedical Engineering, Published online: 05 October 2026; doi:10.1038/s41551-026-01805-5

This Review highlights how organoids and organ-on-a-chip technologies are transforming gastrointestinal disease research by providing clinically relevant models of inflammation, infection and cancer and discusses future opportunities for therapeutic developments.

Nature Biomedical Engineering, Published online: 05 October 2026; doi:10.1038/s41551-026-01806-4

Multi-organ-on-a-chip systems aim to improve the prediction of human drug responses by replicating organ interactions in vitro. This Review discusses advances in niche-preserving engineering, scalable manufacturing and multimodal readouts needed to make these systems reliable tools.

Nature Biomedical Engineering, Published online: 05 October 2026; doi:10.1038/s41551-026-01798-1

A positron emission tomography tracer that directly targets bacterial metabolism by exploiting the phosphotransferase system, a carbohydrate transport pathway absent in mammalian cells, enables selective detection of living bacteria in vivo.

Nature Biomedical Engineering, Published online: 28 September 2026; doi:10.1038/s41551-026-01815-3

Author Correction: Intermittent hypobaric pressure induces selective senescent cell death and alleviates age-related osteoporosis

Nature Biomedical Engineering, Published online: 23 September 2026; doi:10.1038/s41551-026-01791-8

Unsaturated phospholipids unexpectedly form multilamellar, multivesicular liposomes that efficiently encapsulate hydrophilic drugs and suppress burst release. These structures enable ultra-slow drug release and produce weeks-long sciatic nerve block with tetrodotoxin in rats.

Nature Biomedical Engineering, Published online: 23 September 2026; doi:10.1038/s41551-026-01793-6

Contrary to expectations that unsaturation accelerates release, unsaturated phospholipid liposomes showed 3-fold higher loading and markedly reduced initial and sustained release due to multilamellar–multivesicular structure.