Precision proteogenomics analysis of 1,064 cancer patients across ten cancer types unveils the ways in which rare and common germline variants shape the cancer proteome; the findings highlight the contribution of germline genetics in tumor heterogeneity and oncogenesis.

An analytical resource of post-translational modifications from over 1,000 patients across 11 cancer types reveals pan-cancer changes involved in hallmark cancer processes and reveals potential new therapeutic avenues.