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Fluctuating DNA methylation tracks cancer evolution at clinical scale

10 September 2025 at 08:00

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09374-4

Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Phenotypic plasticity and genetic control in colorectal cancer evolution

Nature - Issue - nature.com science feeds

By: Jacob Househam · Timon Heide · George D. Cresswell · Inmaculada Spiteri · Chris Kimberley · Luis Zapata · Claire Lynn · Chela James · Maximilian Mossner · Javier Fernandez-Mateos · Alessandro Vinceti · Ann-Marie Baker · Calum Gabbutt · Alison Berner · Melissa Schmidt

26 October 2022 at 08:00

Nature, Published online: 26 October 2022; doi:10.1038/s41586-022-05311-x

Intratumour genetic ancestry only infrequently affects gene expression traits and subclonal evolution in colorectal cancer, with most genetic intratumour variation having no detected phenotypic consequence and transcriptional plasticity being widespread within a tumour.