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Site-specific DNA insertion into the human genome with engineered recombinases

βœ‡Nature Biotechnology - Issue - nature.com science feeds
By: Alison Fanton Β· Liam J. Bartie Β· Juliana Q. Martins Β· Vincent Q. Tran Β· Laine Goudy Β· Courtney Kernick Β· Matthew G. Durrant Β· Jingyi Wei Β· Zev Armour-Garb Β· April Pawluk Β· Silvana Konermann Β· Alexander Marson Β· Luke A. Gilbert Β· Theodore L. Roth Β· Patrick D. Hsu

Nature Biotechnology, Published online: 06 November 2025; doi:10.1038/s41587-025-02895-3

Engineered DNA recombinases efficiently and specifically insert genetic cargos without the use of landing pads.
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