Nature Biotechnology, Published online: 28 April 2025; doi:10.1038/s41587-025-02650-8

A call for built-in biosecurity safeguards for generative AI tools

Advances in AI and omics enable the creation of AI virtual cells (AIVCs)—multi-scale, multimodal neural network models that simulate molecules, cells, and tissues across diverse states. This vision outlines their design and collaborative development, promising to transform biological research through high-fidelity simulations, accelerating discoveries, and fostering interdisciplinary open science collaborations.