Nature, Published online: 06 August 2025; doi:10.1038/s41586-025-09272-9

A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation and sequence variation.

Nature, Published online: 20 July 2022; doi:10.1038/s41586-022-04965-x

To measure selection on variants, whole-genome sequencing of approximately 150,000 individuals from the UK Biobank is used to rank sequence variants by their level of depletion.