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MirrorMind: Empowering OmniScientist with the Expert Perspectives and Collective Knowledge of Human Scientists

arXiv:2511.16997v1 Announce Type: new Abstract: The emergence of AI Scientists has demonstrated remarkable potential in automating scientific research. However, current approaches largely conceptualize scientific discovery as a solitary optimization or search process, overlooking that knowledge production is inherently a social and historical endeavor. Human scientific insight stems from two distinct yet interconnected sources. First is the individual cognitive trajectory, where a researcher's unique insight is shaped by their evolving research history and stylistic preferences; another is the collective disciplinary memory, where knowledge is sedimented into vast, interconnected networks of citations and concepts. Existing LLMs still struggle to represent these structured, high-fidelity cognitive and social contexts. To bridge this gap, we introduce MirrorMind, a hierarchical cognitive architecture that integrates dual-memory representations within a three-level framework. The Individual Level constructs high-fidelity cognitive models of individual researchers by capturing their episodic, semantic, and persona memories; the Domain Level maps collective knowledge into structured disciplinary concept graphs; and the Interdisciplinary Level that acts as an orthogonal orchestration engine. Crucially, our architecture separates memory storage from agentic execution, enabling AI scientist agents to flexibly access individual memories for unique perspectives or collective structures to reason. We evaluate MirrorMind across four comprehensive tasks, including author-level cognitive simulation, complementary reasoning, cross-disciplinary collaboration promotion, and multi-agent scientific problem solving. The results show that by integrating individual cognitive depth with collective disciplinary breadth, MirrorMind moves beyond simple fact retrieval toward structural, personalized, and insight-generating scientific reasoning.
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Discovery of a novel potent tubulin inhibitor through virtual screening and target validation for cancer chemotherapy

Cell Death Discovery, Published online: 19 August 2025; doi:10.1038/s41420-025-02679-3

Discovery of a novel potent tubulin inhibitor through virtual screening and target validation for cancer chemotherapy
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NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

Nature, Published online: 03 July 2024; doi:10.1038/s41586-024-07620-9

Lactylation of NBS1 by TIP60 promotes homologous recombination-driven DNA repair and resistance to chemotherapy in cancer cells and links altered cancer cell metabolism to increase genome stability.
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Genome-wide characterization of circulating metabolic biomarkers

Nature, Published online: 06 March 2024; doi:10.1038/s41586-024-07148-y

A meta-analysis of genome-wide association studies for 233 circulating metabolites from 33 cohorts reveals more than 400 loci and suggests probable causal genes, providing insights into metabolic pathways and disease aetiology.
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SLC35F2–SYVN1–TRIM59 axis critically regulates ferroptosis of pancreatic cancer cells by inhibiting endogenous p53

Oncogene, Published online: 22 September 2023; doi:10.1038/s41388-023-02843-y

SLC35F2–SYVN1–TRIM59 axis critically regulates ferroptosis of pancreatic cancer cells by inhibiting endogenous p53
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