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Starfysh integrates spatial transcriptomic and histologic data to reveal heterogeneous tumor–immune hubs

21 March 2024 at 08:00

Nature Biotechnology, Published online: 21 March 2024; doi:10.1038/s41587-024-02173-8

Reference-free integrative analysis of spatial transcriptomics data is achieved with archetype analysis.

Spatial epigenome–transcriptome co-profiling of mammalian tissues

Nature - Issue - nature.com science feeds

By: Di Zhang · Yanxiang Deng · Petra Kukanja · Eneritz Agirre · Marek Bartosovic · Mingze Dong · Cong Ma · Sai Ma · Graham Su · Shuozhen Bao · Yang Liu · Yang Xiao · Gorazd B. Rosoklija · Andrew J. Dwork · J. John Mann · Kam W. Leong · Maura Boldrini · Liya Wang · Maximilian

15 March 2023 at 08:00

Nature, Published online: 15 March 2023; doi:10.1038/s41586-023-05795-1

The authors present two technologies for spatially resolved, genome-wide, joint profiling of the epigenome and transcriptome by cosequencing chromatin accessibility and gene expression, or histone modifications and gene expression on the same tissue section at near-single-cell resolution.