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From Clicks to Preference: A Multi-stage Alignment Framework for Generative Query Suggestion in Conversational System

arXiv:2508.15811v2 Announce Type: replace-cross Abstract: Generative query suggestion using large language models offers a powerful way to enhance conversational systems, but aligning outputs with nuanced user preferences remains a critical challenge. To address this, we introduce a multi-stage framework designed for progressive alignment between the generation policy and user intent. Our pipeline begins with prompt engineering as a cold-start strategy, followed by the Supervised Fine-Tuning stage, in which we introduce a distillation method on click logs to create a robust foundational model. To better model user preferences while capturing their inherent uncertainty, we develop a Gaussian Reward Model (GaRM) that represents user preferences as probability distributions rather than point estimates. Finally, we employ reinforcement learning to align the generation policy with these preferences, guided by a composite reward function that integrates GaRM with auxiliary heuristics to mitigate reward hacking. To maintain training stability, this process is enhanced by a novel out-of-distribution regularization method and a two-stage reward fusion technique. Extensive experiments demonstrate that our framework significantly outperforms baselines on both automatic and human evaluations and yields a 34\% relative increase in user engagement as measured by click-through rate in live A/B tests.
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Artificial intelligence in pancreatitis: A narrative review on advancing precision diagnosis, prognosis, and therapeutic strategies

World J Gastroenterol. 2025 Oct 21;31(39):110971. doi: 10.3748/wjg.v31.i39.110971.

ABSTRACT

Pancreatitis poses persistent diagnostic and therapeutic challenges due to its heterogeneous clinical presentation, variable disease course, and lack of targeted interventions. Conventional tools, such as serum enzymes, cross-sectional imaging and clinical scoring systems, often exhibit limited sensitivity and prognostic value, especially during early or atypical stages. Moreover, therapeutic development remains slow, with limited progress toward personalized or mechanism-based strategies. These limitations highlight a critical need for integrative data-driven approaches. Artificial intelligence (AI) has emerged as a promising tool to enhance clinical decision-making in pancreatitis. This narrative review synthesizes recent progress in AI applications across three domains. First, AI-enabled diagnostic platforms incorporating radiomics, deep learning-based imaging analysis, and biomarker optimization have improved early detection and differentiation of pancreatic diseases. Second, AI-driven prognostic models now allow real-time severity prediction, complication forecasting, and recurrence risk assessment, some of which have been deployed in hospital information systems for intensive care units and mortality risk triage. Third, AI-assisted drug discovery and network pharmacology, particularly in combination with traditional Chinese medicine, have revealed novel therapeutic opportunities. Despite encouraging developments, challenges remain in data standardization, model transparency and clinical validation. A multidisciplinary strategy integrating omics data, longitudinal monitoring and pharmacological modeling may help bridge current gaps and advance precision medicine in pancreatitis care.

PMID:41180795 | PMC:PMC12576603 | DOI:10.3748/wjg.v31.i39.110971

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Systems-level immunomonitoring in children with solid tumors to enable precision medicine

In a population-based cohort of 191 children with diverse solid tumors, systems-level analyses unravel immune variation with age and tumor type and provide a reference for future precision immunotherapies tailored for the evolving immune systems of children.
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Purine salvage–associated metabolites as biomarkers for early diagnosis of esophageal squamous cell carcinoma: a diagnostic model–based study

Cell Death Discovery, Published online: 14 March 2024; doi:10.1038/s41420-024-01896-6

Purine salvage–associated metabolites as biomarkers for early diagnosis of esophageal squamous cell carcinoma: a diagnostic model–based study
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