arXiv:2512.22149v1 Announce Type: cross Abstract: Multi-agent systems powered by large language models have emerged as a promising paradigm for solving complex reasoning tasks through collaborative intelligence. However, efficiently deploying these systems on serverless GPU platforms presents significant resource allocation challenges due to heterogeneous agent workloads, varying computational demands, and the need for cost-effective scaling. This paper presents an adaptive GPU resource allocation framework that achieves 85\% latency reduction compared to round-robin scheduling while maintaining comparable throughput to static allocation, using an $O(N)$ complexity algorithm for real-time adaptation. Our approach dynamically allocates GPU resources based on workload characteristics, agent priorities, and minimum resource requirements, enabling efficient utilization while maintaining quality of service. The framework addresses three key challenges: (1) heterogeneous computational demands across lightweight coordinators and heavyweight specialists, (2) dynamic workload fluctuations requiring millisecond-scale reallocation, and (3) capacity constraints in serverless environments. Through comprehensive simulations modeling realistic multi-agent workflows with four heterogeneous agents, we demonstrate that adaptive allocation outperforms static equal and round-robin strategies across latency, cost, and GPU utilization metrics. The framework provides a practical solution for deploying cost-efficient multi-agent AI systems on serverless GPU infrastructure.

arXiv:2511.00209v1 Announce Type: cross Abstract: Diffusion models have emerged as a leading framework in generative modeling, showing significant potential to accelerate and transform the traditionally slow and costly process of drug discovery. This review provides a systematic comparison of their application in designing two principal therapeutic modalities: small molecules and therapeutic peptides. We analyze how a unified framework of iterative denoising is adapted to the distinct molecular representations, chemical spaces, and design objectives of each modality. For small molecules, these models excel at structure-based design, generating novel, pocket-fitting ligands with desired physicochemical properties, yet face the critical hurdle of ensuring chemical synthesizability. Conversely, for therapeutic peptides, the focus shifts to generating functional sequences and designing de novo structures, where the primary challenges are achieving biological stability against proteolysis, ensuring proper folding, and minimizing immunogenicity. Despite these distinct challenges, both domains face shared hurdles: the need for more accurate scoring functions, the scarcity of high-quality experimental data, and the crucial requirement for experimental validation. We conclude that the full potential of diffusion models will be unlocked by bridging these modality-specific gaps and integrating them into automated, closed-loop Design-Build-Test-Learn (DBTL) platforms, thereby shifting the paradigm from chemical exploration to the targeted creation of novel therapeutics.

Nature Biotechnology, Published online: 01 March 2024; doi:10.1038/s41587-023-02097-9

Iniquitate quantifies the effects of cell type imbalance on single-cell RNA sequencing data integration.

Oncogene, Published online: 01 December 2023; doi:10.1038/s41388-023-02902-4

RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4