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Multimodal Foundation Models for Early Disease Detection

arXiv:2510.01899v2 Announce Type: replace-cross Abstract: Healthcare data now span EHRs, medical imaging, genomics, and wearable sensors, but most diagnostic models still process these modalities in isolation. This limits their ability to capture early, cross-modal disease signatures. This paper introduces a multimodal foundation model built on a transformer architecture that integrates heterogeneous clinical data through modality-specific encoders and cross-modal attention. Each modality is mapped into a shared latent space and fused using multi-head attention with residual normalization. We implement the framework using a multimodal dataset that simulates early-stage disease patterns across EHR sequences, imaging patches, genomic profiles, and wearable signals, including missing-modality scenarios and label noise. The model is trained using supervised classification together with self-supervised reconstruction and contrastive alignment to improve robustness. Experimental evaluation demonstrates strong performance in early-detection settings, with stable classification metrics, reliable uncertainty estimates, and interpretable attention patterns. The approach moves toward a flexible, pretrain-and-fine-tune foundation model that supports precision diagnostics, handles incomplete inputs, and improves early disease detection across oncology, cardiology, and neurology applications.
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Explaining the Unexplainable: A Systematic Review of Explainable AI in Finance

arXiv:2503.05966v3 Announce Type: replace-cross Abstract: Practitioners and researchers trying to strike a balance between accuracy and transparency center Explainable Artificial Intelligence (XAI) at the junction of finance. This paper offers a thorough overview of the changing scene of XAI applications in finance together with domain-specific implementations, methodological developments, and trend mapping of research. Using bibliometric and content analysis, we find topic clusters, significant research, and most often used explainability strategies used in financial industries. Our results show a substantial dependence on post-hoc interpretability techniques; attention mechanisms, feature importance analysis and SHAP are the most often used techniques among them. This review stresses the need of multidisciplinary approaches combining financial knowledge with improved explainability paradigms and exposes important shortcomings in present XAI systems.
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