arXiv:2512.01241v2 Announce Type: replace-cross Abstract: Large language models (LLMs) are routinely used by physicians and patients for medical advice, yet their clinical safety profiles remain poorly characterized. We present NOHARM (Numerous Options Harm Assessment for Risk in Medicine), a benchmark using 100 real primary care-to-specialist consultation cases to measure frequency and severity of harm from LLM-generated medical recommendations. NOHARM covers 10 specialties, with 12,747 expert annotations for 4,249 clinical management options. Across 31 LLMs, potential for severe harm from LLM recommendations occurs in up to 22.2% (95% CI 21.6-22.8%) of cases, with harm of omission accounting for 76.6% (95% CI 76.4-76.8%) of errors. Safety performance is only moderately correlated (r = 0.61-0.64) with existing AI and medical knowledge benchmarks. The best models outperform generalist physicians on safety (mean difference 9.7%, 95% CI 7.0-12.5%), and a diverse multi-agent approach improves safety compared to solo models (mean difference 8.0%, 95% CI 4.0-12.1%). Therefore, despite strong performance on existing evaluations, widely used AI models can produce severely harmful medical advice at nontrivial rates, underscoring clinical safety as a distinct performance dimension necessitating explicit measurement.

arXiv:2512.06734v1 Announce Type: cross Abstract: Transfer Learning (TL) has accelerated the rapid development and availability of large language models (LLMs) for mainstream natural language processing (NLP) use cases. However, training and deploying such gigantic LLMs in resource-constrained, real-world healthcare situations remains challenging. This study addresses the limited support available to visually impaired users and speakers of low-resource languages such as Hindi who require medical assistance in rural environments. We propose PDFTEMRA (Performant Distilled Frequency Transformer Ensemble Model with Random Activations), a compact transformer-based architecture that integrates model distillation, frequency-domain modulation, ensemble learning, and randomized activation patterns to reduce computational cost while preserving language understanding performance. The model is trained and evaluated on medical question-answering and consultation datasets tailored to Hindi and accessibility scenarios, and its performance is compared against standard NLP state-of-the-art model baselines. Results demonstrate that PDFTEMRA achieves comparable performance with substantially lower computational requirements, indicating its suitability for accessible, inclusive, low-resource medical NLP applications.