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OS-Symphony: A Holistic Framework for Robust and Generalist Computer-Using Agent

arXiv:2601.07779v1 Announce Type: cross Abstract: While Vision-Language Models (VLMs) have significantly advanced Computer-Using Agents (CUAs), current frameworks struggle with robustness in long-horizon workflows and generalization in novel domains. These limitations stem from a lack of granular control over historical visual context curation and the absence of visual-aware tutorial retrieval. To bridge these gaps, we introduce OS-Symphony, a holistic framework that comprises an Orchestrator coordinating two key innovations for robust automation: (1) a Reflection-Memory Agent that utilizes milestone-driven long-term memory to enable trajectory-level self-correction, effectively mitigating visual context loss in long-horizon tasks; (2) Versatile Tool Agents featuring a Multimodal Searcher that adopts a SeeAct paradigm to navigate a browser-based sandbox to synthesize live, visually aligned tutorials, thereby resolving fidelity issues in unseen scenarios. Experimental results demonstrate that OS-Symphony delivers substantial performance gains across varying model scales, establishing new state-of-the-art results on three online benchmarks, notably achieving 65.84% on OSWorld.
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Cancer-Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic Targets

MedComm (2020). 2025 Jul 11;6(7):e70292. doi: 10.1002/mco2.70292. eCollection 2025 Jul.

ABSTRACT

Cancer-associated fibroblasts (CAFs) are functionally diverse stromal regulators that orchestrate tumor progression, metastasis, and therapy resistance through dynamic crosstalk within the tumor microenvironment (TME). Recent advances in single-cell multiomics and spatial transcriptomics have identified conserved CAF subtypes with distinct molecular signatures, spatial distributions, and context-dependent roles, highlighting their dual capacity to promote immunosuppression or restrain tumor growth. However, therapeutic strategies struggle to reconcile this functional duality, hindering clinical translation. This review systematically categorizes CAF subtypes by origin, biomarkers, and TME-specific functions, focusing on their roles in chemoresistance, maintenance of stemness, and formation of immunosuppressive niches. We evaluate emerging targeting approaches, including selective depletion of tumor-promoting subsets (e.g., fibroblast activation protein+ CAFs), epigenetic reprogramming toward antitumor phenotypes, and inhibition of CXCL12/CXCR4 or transforming growth factor-beta signaling pathways. Spatial multiomics-driven combinatorial therapies, such as the synergistic use of CAFs and immune checkpoint inhibitors, are highlighted as strategies to overcome microenvironment-driven resistance. By integrating CAF biology with translational advances, this work provides a roadmap for developing subtype-specific biomarkers and precision stromal therapies, directly informing efforts to disrupt tumor-stroma coevolution. Key concepts include spatial transcriptomics, stromal reprogramming, and tumor-stroma coevolution, offering actionable insights for both mechanistic research and clinical innovation.

PMID:40656546 | PMC:PMC12246558 | DOI:10.1002/mco2.70292

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