Senescence-driven molecular subtyping in pancreatic cancer: a multi-omics framework for precision medicine

By: Meilong Shi · Penghao Li · Bo Li · Huan Wang · Xiaoyi Yin · Xiaohan Shi · Suizhi Gao · Yikai Li · Chuanqi Teng · Shuai Yuan · Xinyu Liu · Zhendong Fu · Xiaochao Kang · Wei Jin · Bin Song · Kailian Zheng · Yijie Zhang · Xiongfei Xu · Shiwei Guo · Gang Jin

15 December 2025 at 19:00

BMC Cancer. 2025 Dec 15. doi: 10.1186/s12885-025-15341-z. Online ahead of print.

NO ABSTRACT

PMID:41398222 | DOI:10.1186/s12885-025-15341-z

A full life cycle biological clock based on routine clinical data and its impact in health and diseases

Nature Medicine

By: Kai Wang · Fei Liu · Wei Wu · Changxi Hu · Xian Shen · Meihao Wang · Gen Li · Fanxin Zeng · Li Liu · Io Nam Wong · Sian Liu · Zixing Zou · Bingzhou Li · Jinghang Li · Xiaoying Huang · Shengwei Jin · Zhuomin Li · Hui Xu · Gang Chen · Xiaodong Chen · Ying Zhu · Ping Li · Zhe Feng · Winston Wang · Linling Cheng · Mingqi Yang · Qiang Hou · Wenyang Lu · Yiwen Sun · Kun Li · Tian Zhong · Zhuo Sun · Yun Yin · Alexandre Loupy · Eric Oermann · Xiangmei Chen · Kang Zhang · Manson Fok · Taiwa Hou · Lei Guo · Miaosang Xu · Dan Yao · Chengjing Wang · Pingzhen Yang · Caiwen Ou · Xueqiang Wang · Aimin Wu

27 October 2025 at 08:00

Nature Medicine, Published online: 27 October 2025; doi:10.1038/s41591-025-04006-w

The biological clock model LifeClock predicts biological age across all life stages from routine clinical data, revealing distinct pediatric and adult disease risk patterns.

Identifying specific functional roles for senescence across cell types

Cell

By: Huan Zhao · Zixin Liu · Hui Chen · Maoying Han · Mingjun Zhang · Kuo Liu · Hengwei Jin · Xiuxiu Liu · Mengyang Shi · Wenjuan Pu · Markus Werner · Michael Meister · Stefan G. Kauschke · Ruilin Sun · Jinjin Wang · Ruling Shen · Qing-Dong Wang · Xin Ma · Jan S. Tchorz · Bin Zhou

4 October 2024 at 08:00

A dual recombinase-mediated genetic system for cell-type-specific lineage tracing, ablation, and gene manipulation of senescent cells reveals distinct roles of senescence across cell types.

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