arXiv:2601.11560v1 Announce Type: cross Abstract: Biomedical knowledge graphs (KGs) encode vast, heterogeneous information spanning literature, genes, pathways, drugs, diseases, and clinical trials, but leveraging them collectively for scientific discovery remains difficult. Their structural differences, continual evolution, and limited cross-resource alignment require substantial manual integration, limiting the depth and scale of knowledge exploration. We introduce DeepEvidence, an AI-agent framework designed to perform Deep Research across various heterogeneous biomedical KGs. Unlike generic Deep Research systems that rely primarily on internet-scale text, DeepEvidence incorporates specialized knowledge-graph tooling and coordinated exploration strategies to systematically bridge heterogeneous resources. At its core is an orchestrator that directs two complementary agents: Breadth-First ReSearch (BFRS) for broad, multi-graph entity search, and Depth-First ReSearch (DFRS) for multi-hop, evidence-focused reasoning. An internal, incrementally built evidence graph provides a structured record of retrieved entities, relations, and supporting evidence. To operate at scale, DeepEvidence includes unified interfaces for querying diverse biomedical APIs and an execution sandbox that enables programmatic data retrieval, extraction, and analysis. Across established deep-reasoning benchmarks and four key stages of the biomedical discovery lifecycle: drug discovery, pre-clinical experimentation, clinical trial development, and evidence-based medicine, DeepEvidence demonstrates substantial gains in systematic exploration and evidence synthesis. These results highlight the potential of knowledge-graph-driven Deep Research to accelerate biomedical discovery.

arXiv:2512.13438v1 Announce Type: cross Abstract: While Large Language Model (LLM) agents show great potential for automated UI navigation such as automated UI testing and AI assistants, their efficiency has been largely overlooked. Our motivating study reveals that inefficient UI representation creates a critical performance bottleneck. However, UI representation optimization, formulated as the task of automatically generating programs that transform UI representations, faces two unique challenges. First, the lack of Boolean oracles, which traditional program synthesis uses to decisively validate semantic correctness, poses a fundamental challenge to co-optimization of token efficiency and completeness. Second, the need to process large, complex UI trees as input while generating long, compositional transformation programs, making the search space vast and error-prone. Toward addressing the preceding limitations, we present UIFormer, the first automated optimization framework that synthesizes UI transformation programs by conducting constraint-based optimization with structured decomposition of the complex synthesis task. First, UIFormer restricts the program space using a domain-specific language (DSL) that captures UI-specific operations. Second, UIFormer conducts LLM-based iterative refinement with correctness and efficiency rewards, providing guidance for achieving the efficiency-completeness co-optimization. UIFormer operates as a lightweight plugin that applies transformation programs for seamless integration with existing LLM agents, requiring minimal modifications to their core logic. Evaluations across three UI navigation benchmarks spanning Android and Web platforms with five LLMs demonstrate that UIFormer achieves 48.7% to 55.8% token reduction with minimal runtime overhead while maintaining or improving agent performance. Real-world industry deployment at WeChat further validates the practical impact of UIFormer.

arXiv:2510.27617v1 Announce Type: new Abstract: Automation of Register Transfer Level (RTL) design can help developers meet increasing computational demands. Large Language Models (LLMs) show promise for Hardware Description Language (HDL) generation, but face challenges due to limited parametric knowledge and domain-specific constraints. While prompt engineering and fine-tuning have limitations in knowledge coverage and training costs, multi-agent architectures offer a training-free paradigm to enhance reasoning through collaborative generation. However, current multi-agent approaches suffer from two critical deficiencies: susceptibility to noise propagation and constrained reasoning space exploration. We propose VeriMoA, a training-free mixture-of-agents (MoA) framework with two synergistic innovations. First, a quality-guided caching mechanism to maintain all intermediate HDL outputs and enables quality-based ranking and selection across the entire generation process, encouraging knowledge accumulation over layers of reasoning. Second, a multi-path generation strategy that leverages C++ and Python as intermediate representations, decomposing specification-to-HDL translation into two-stage processes that exploit LLM fluency in high-resource languages while promoting solution diversity. Comprehensive experiments on VerilogEval 2.0 and RTLLM 2.0 benchmarks demonstrate that VeriMoA achieves 15--30% improvements in Pass@1 across diverse LLM backbones, especially enabling smaller models to match larger models and fine-tuned alternatives without requiring costly training.

Nature Medicine, Published online: 08 September 2025; doi:10.1038/s41591-025-03859-5

Building the world’s first truly global medical foundation model

Nature Medicine, Published online: 28 August 2025; doi:10.1038/s41591-025-03900-7

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Nature, Published online: 22 May 2024; doi:10.1038/s41586-024-07441-w

Prov-GigaPath, a whole-slide pathology foundation model pretrained on a large dataset containing around 1.3 billion pathology images, attains state-of-the-art performance in cancer classification and pathomics tasks.