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A tumor-on-a-chip for in vitro study of CAR-T cell immunotherapy in solid tumors

Nature Biotechnology - Issue - nature.com science feeds

By: Haijiao Liu · Estela Noguera-Ortega · Xuanqi Dong · Won Dong Lee · Jeehan Chang · Sezin Aday Aydin · Yumei Li · Yonghee Shin · Xinyi Shi · Maria Liousia · Marina C. Martinez · Joshua J. Brotman · Soyeon Kim · Zeyu Chen · Anni Wang · Zirui Ou · Jungwook Paek · Ju Young Park · Aidi Liu · Haonan Hu · Zebin Xiao · Dora Maria Racca · Se-jeong Kim · G. Scott Worthen · Wei Guo · Ellen Puré · Taewook Kang · Joshua D. Rabinowitz · E. John Wherry · Edmund K. Moon · Steven M. Albelda · Dan Dongeun Huh

17 October 2025 at 08:00

Nature Biotechnology, Published online: 17 October 2025; doi:10.1038/s41587-025-02845-z

The interactions of CAR-T cells and solid tumors are modeled on a chip.

Spatial metabolic gradients in the liver and small intestine

Nature - Issue - nature.com science feeds

By: Laith Z. Samarah · Clover Zheng · Xi Xing · Won Dong Lee · Amichay Afriat · Uthsav Chitra · Michael R. MacArthur · Wenyun Lu · Connor S. R. Jankowski · Cong Ma · Craig J. Hunter · Michael Neinast · Daniel R. Weilandt · Benjamin J. Raphael · Joshua D. Rabinowitz

15 October 2025 at 08:00

Nature, Published online: 15 October 2025; doi:10.1038/s41586-025-09616-5

Mapping of spatial metabolic gradients in the mouse liver and intestine identifies fructose-induced focal derangements in liver metabolism.