arXiv:2601.14525v1 Announce Type: cross Abstract: Automated AI research holds great potential to accelerate scientific discovery. However, current LLMs often generate plausible-looking but ineffective ideas. Execution grounding may help, but it is unclear whether automated execution is feasible and whether LLMs can learn from the execution feedback. To investigate these, we first build an automated executor to implement ideas and launch large-scale parallel GPU experiments to verify their effectiveness. We then convert two realistic research problems - LLM pre-training and post-training - into execution environments and demonstrate that our automated executor can implement a large fraction of the ideas sampled from frontier LLMs. We analyze two methods to learn from the execution feedback: evolutionary search and reinforcement learning. Execution-guided evolutionary search is sample-efficient: it finds a method that significantly outperforms the GRPO baseline (69.4% vs 48.0%) on post-training, and finds a pre-training recipe that outperforms the nanoGPT baseline (19.7 minutes vs 35.9 minutes) on pre-training, all within just ten search epochs. Frontier LLMs often generate meaningful algorithmic ideas during search, but they tend to saturate early and only occasionally exhibit scaling trends. Reinforcement learning from execution reward, on the other hand, suffers from mode collapse. It successfully improves the average reward of the ideator model but not the upper-bound, due to models converging on simple ideas. We thoroughly analyze the executed ideas and training dynamics to facilitate future efforts towards execution-grounded automated AI research.

Nature Biotechnology, Published online: 05 January 2026; doi:10.1038/s41587-025-02974-5

RNA’s dynamic nature and complex physiochemical properties make it difficult to structurally resolve. This Perspectives examines how integrating experimental and computational approaches to structure determination can address this challenge.

arXiv:2510.22780v2 Announce Type: replace Abstract: AI agents are continually optimized for tasks related to human work, such as software engineering and professional writing, signaling a pressing trend with significant impacts on the human workforce. However, these agent developments have often not been grounded in a clear understanding of how humans execute work, to reveal what expertise agents possess and the roles they can play in diverse workflows. In this work, we study how agents do human work by presenting the first direct comparison of human and agent workers across multiple essential work-related skills: data analysis, engineering, computation, writing, and design. To better understand and compare heterogeneous computer-use activities of workers, we introduce a scalable toolkit to induce interpretable, structured workflows from either human or agent computer-use activities. Using such induced workflows, we compare how humans and agents perform the same tasks and find that: (1) While agents exhibit promise in their alignment to human workflows, they take an overwhelmingly programmatic approach across all work domains, even for open-ended, visually dependent tasks like design, creating a contrast with the UI-centric methods typically used by humans. (2) Agents produce work of inferior quality, yet often mask their deficiencies via data fabrication and misuse of advanced tools. (3) Nonetheless, agents deliver results 88.3% faster and cost 90.4-96.2% less than humans, highlighting the potential for enabling efficient collaboration by delegating easily programmable tasks to agents.

arXiv:2510.22780v1 Announce Type: new Abstract: AI agents are continually optimized for tasks related to human work, such as software engineering and professional writing, signaling a pressing trend with significant impacts on the human workforce. However, these agent developments have often not been grounded in a clear understanding of how humans execute work, to reveal what expertise agents possess and the roles they can play in diverse workflows. In this work, we study how agents do human work by presenting the first direct comparison of human and agent workers across multiple essential work-related skills: data analysis, engineering, computation, writing, and design. To better understand and compare heterogeneous computer-use activities of workers, we introduce a scalable toolkit to induce interpretable, structured workflows from either human or agent computer-use activities. Using such induced workflows, we compare how humans and agents perform the same tasks and find that: (1) While agents exhibit promise in their alignment to human workflows, they take an overwhelmingly programmatic approach across all work domains, even for open-ended, visually dependent tasks like design, creating a contrast with the UI-centric methods typically used by humans. (2) Agents produce work of inferior quality, yet often mask their deficiencies via data fabrication and misuse of advanced tools. (3) Nonetheless, agents deliver results 88.3% faster and cost 90.4-96.2% less than humans, highlighting the potential for enabling efficient collaboration by delegating easily programmable tasks to agents.

Cell Death Discovery, Published online: 03 July 2024; doi:10.1038/s41420-024-02075-3

The emerging role of nuclear receptor coactivator 4 in health and disease: a novel bridge between iron metabolism and immunity

DrugMap serves as a roadmap to develop covalent ligands for oncogenic drivers.

Nature, Published online: 20 September 2023; doi:10.1038/s41586-023-06535-1

A scalable total synthesis of portimines enables structural reassignment of portimine B and in-depth functional evaluation of portimine A, revealing that portimine A induces translation inhibition selectively in human cancer cells and is efficacious in vivo tumour-clearance models.