Advances in AI and omics enable the creation of AI virtual cells (AIVCs)—multi-scale, multimodal neural network models that simulate molecules, cells, and tissues across diverse states. This vision outlines their design and collaborative development, promising to transform biological research through high-fidelity simulations, accelerating discoveries, and fostering interdisciplinary open science collaborations.

Nature, Published online: 23 December 2024; doi:10.1038/s41586-024-08555-x

Author Correction: π-HuB: the proteomic navigator of the human body

A multiscale drug discovery platform integrating human induced pluripotent stem cells, 3D-engineered heart tissues, and animal models identifies artesunate as a safe and potent antifibrotic compound.

Nature, Published online: 20 December 2024; doi:10.1038/d41586-024-04160-0

More than 100 clinical trials put stem cells for regenerative medicine to the test. It’s a turning point for a field beset with ethical and political controversy.

Nature, Published online: 20 December 2024; doi:10.1038/d41586-024-04178-4

PAGERs provide modular, customizable G-protein-coupled receptors for cell-signalling studies.

Nature, Published online: 19 December 2024; doi:10.1038/d41586-024-04172-w

Proteins could serve as biomarkers for senescent cells, which have stopped dividing but have not yet died.

A dual recombinase-mediated genetic system for cell-type-specific lineage tracing, ablation, and gene manipulation of senescent cells reveals distinct roles of senescence across cell types.

A research team has developed a groundbreaking technology that can treat colon cancer by converting cancer cells into a state resembling normal colon cells without killing them, thus avoiding side effects.

Hospitals that have adopted the Center for Medicare and Medicaid (CMS) 'hospital-at-home' program, which serves as an alternative to admission to brick-and-mortar facilities, are concentrated in large, urban, not-for-profit, and academic hospitals, highlighting need for targeted incentives to expand program to smaller, rural, and non-teaching hospitals.

Nature, Published online: 18 December 2024; doi:10.1038/d41586-024-04109-3

A battery-like technology uses a metal called tantalum to create an equivalent of digital 0s and 1s.

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08333-9

Motif grammar on nucleosome fibres acts as signpost elements, directing TF combinatorial binding to enhancers.

Scientists have uncovered new details about the mechanism behind cancer progression. Researchers explored the influence the mechanical stiffening of the tumor cell's environment may have on the structure and function of the nucleus.

Advances in solid-state battery research are paving the way for safer, longer-lasting energy storage solutions. A recent review highlights breakthroughs in inorganic solid electrolytes and their role in improving battery performance. The study also addresses key challenges, such as interfacial compatibility, while proposing innovative strategies for next-generation battery technologies.

Researchers trained a large language model to read medical charts, looking for signs that kids with ADHD received the right follow-up care when using new medications.