Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07370-8

Enhanced light–molecule interactions in high-finesse fibre-based Fabry–Pérot microcavities are used to detect and profile individual unlabelled solution-phase biomolecules, leading to potential applications in the life and chemical sciences.

Characterization of microbiome genomes at the species level in over 4,000 metastatic tumor biopsies identifies the distribution and diversity features of tumor-resident bacterial DNA at a pan-cancer scale, highlighting the associations between microbial community dynamics and tumor immunity and immunotherapy efficacy.

Nature, Published online: 08 April 2024; doi:10.1038/s41586-024-07379-z

Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer

Immunotherapy holds strong promise for cancer treatment but at present benefits only a small proportion of cases. A pan-cancer analysis of the immune landscape in more than 1,000 tumors across ten cancer types reveals immune surveillance and immune evasion mechanisms as well as potential molecular target that could augment future immunotherapy and precision medicine strategies.

Nature, Published online: 06 December 2023; doi:10.1038/s41586-023-06802-1

Blood plasma protein data was combined with machine learning models for a simple method to determine differences in organ-specific aging; the study provides a basis for the prediction of diseases and aging effects using plasma proteomics.

Mexican, Puerto Rican, and Central American Ancestry (MPRCA) individuals represent 82% of US Latinos. An intergenerational group of MPRCA women and allies met to discuss persistent underrepresentation of MPRCA women in STEM, identifying multi-level challenges and solutions. Implementation of these solutions is important and will benefit MPRCA and the entire academic community.

Oncogene, Published online: 18 October 2023; doi:10.1038/s41388-023-02868-3

Metabolic control of cancer metastasis: role of amino acids at secondary organ sites

Nature, Published online: 06 September 2023; doi:10.1038/d41586-023-02733-z

Physicist Ranga Dias and his colleagues have twice claimed to make a room-temperature superconductor. But many researchers question the evidence.

Nature Biotechnology, Published online: 22 August 2023; doi:10.1038/s41587-023-01952-z

Author Correction: Guidelines for public database submission of uncultivated virus genome sequences for taxonomic classification

Oncogene, Published online: 19 July 2023; doi:10.1038/s41388-023-02784-6

Editorial Expression of Concern: Overexpression of CEACAM6 promotes insulin-like growth factor I-induced pancreatic adenocarcinoma cellular invasiveness

Nature, Published online: 19 July 2023; doi:10.1038/s41586-023-05915-x

Intestinal cell types are organized into distinct neighbourhoods and communities within the healthy human intestine, with distinct immunological niches.

Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-06054-z

The genomic differences between primary and metastatic tumours are assessed across 23 cancer types using pan-cancer whole-genome analysis.

Oncogene, Published online: 10 November 2022; doi:10.1038/s41388-022-02513-5

Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1