DrugMap serves as a roadmap to develop covalent ligands for oncogenic drivers.

Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07380-6

Reducing greenhouse gas emissions, managing ecosystem health, and preventing biological invasions and biodiversity loss could help to reduce the burden of plant, animal and human diseases, especially when coupled with improvements to social and economic determinants of health.

Nature, Published online: 01 May 2024; doi:10.1038/s41586-024-07359-3

Quantitative multimodal 3D reconstruction of human pancreatic tissue at single-cell resolution reveals a high burden of multifocal, genetically heterogeneous pancreatic intraepithelial neoplasias in the normal adult pancreas.

Nature, Published online: 10 April 2024; doi:10.1038/d41586-024-01043-2

The bioengineered immune players called CAR T cells last longer and work better if pumped up with a large dose of a protein that makes them resemble stem cells.

Epigenetic Scores (EpiScores) for blood protein levels have been associated with disease outcomes and measures of brain health, highlighting their potential usefulness as clinical biomarkers. They are typicall...

Nature, Published online: 11 March 2024; doi:10.1038/d41586-024-00673-w

Therapy built on tumour-infiltrating lymphocytes is now being prepared for at least 20 people in the United States with advanced melanoma.

Immunotherapy holds strong promise for cancer treatment but at present benefits only a small proportion of cases. A pan-cancer analysis of the immune landscape in more than 1,000 tumors across ten cancer types reveals immune surveillance and immune evasion mechanisms as well as potential molecular target that could augment future immunotherapy and precision medicine strategies.

Nature, Published online: 15 January 2024; doi:10.1038/s41586-024-07050-7

Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes

Nature, Published online: 15 November 2023; doi:10.1038/s41586-023-06740-y

Experiments in mice show that expression of the oncogene SmoM2 induces basal cell carcinoma in the ear epidermis but not in the back skin, and that this difference in susceptibility is regulated by the extracellular matrix.

B vitamins such as folate (B9), B6, and B12 are key in one carbon metabolism, which generates methyl donors for DNA methylation. Several studies have linked differential methylation to self-reported intakes of...

Nature, Published online: 12 September 2023; doi:10.1038/d41586-023-02861-6

SDG 14.5: at last, a breakthrough for the 2030 agenda

Nature, Published online: 27 July 2023; doi:10.1038/s41586-023-06455-0

Publisher Correction: Large language models encode clinical knowledge

Nature, Published online: 12 July 2023; doi:10.1038/s41586-023-06291-2

Med-PaLM, a state-of-the-art large language model for medicine, is introduced and evaluated across several medical question answering tasks, demonstrating the promise of these models in this domain.

Nature, Published online: 15 May 2023; doi:10.1038/d41586-023-01610-z

Genetic resilience found in a person predisposed to early-onset dementia could potentially lead to new treatments.

Nature, Published online: 01 February 2023; doi:10.1038/s41586-022-05672-3

Using imaging mass cytometry, the tumour and immunological spatial landscapes of 416 lung adenocarcinomas are characterized, which, when combined with deep learning, can predict clinical outcomes with high accuracy.

Nature, Published online: 09 November 2022; doi:10.1038/s41586-022-05425-2

A workflow centred around base-specific in situ sequencing generates detailed maps of, and can phenotypically characterize, the unique set of subclones of cancers.

Oncogene, Published online: 10 October 2022; doi:10.1038/s41388-022-02487-4

Nature, Published online: 05 October 2022; doi:10.1038/s41586-022-05169-z

Cleaved and intact type I collagen have different effects on pancreatic ductal adenocarcinoma (PDAC), and remodelling of type I collagen—mediated through DDR1 signalling—is a prognostic indicator for the survival of patients with PDAC.

Nature, Published online: 20 July 2022; doi:10.1038/s41586-022-04975-9

Deep whole-genome sequencing of serial blood samples and matched metastatic tissue reveals that circulating tumour DNA profiling enables detailed study of treatment-driven subclone dynamics, epigenomics and genome-wide somatic evolution in metastatic human cancers.

Despite the efforts to describe the molecular landscape of esophageal adenocarcinoma (EAC) and its precursor lesion Barrett’s esophagus (BE), discrepant findings are reported. Here, we investigated the prevale...