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Systems-level design principles of metabolic rewiring in an animal

Nature - Issue - nature.com science feeds

By: Xuhang Li · Hefei Zhang · Thomas Hodder · Wen Wang · Chad L. Myers · L. Safak Yilmaz · Albertha J. M. Walhout

26 February 2025 at 08:00

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08636-5

Systems-level Worm Perturb-Seq of metabolic genes reveals design principles of transcriptional metabolic rewiring, many of which can be explained by a compensation–repression model.

Deep whole-genome analysis of 494 hepatocellular carcinomas

Nature - Issue - nature.com science feeds

By: Lei Chen · Chong Zhang · Ruidong Xue · Mo Liu · Jian Bai · Jinxia Bao · Yin Wang · Nanhai Jiang · Zhixuan Li · Wenwen Wang · Ruiru Wang · Bo Zheng · Airong Yang · Ji Hu · Ke Liu · Siyun Shen · Yangqianwen Zhang · Mixue Bai · Yan Wang · Yanjing Zhu · Shuai Yang · Qiang Gao · Jin Gu · Dong Gao · Xin Wei Wang · Hidewaki Nakagawa · Ning Zhang · Lin Wu · Steven G. Rozen · Fan Bai · Hongyang Wang

14 February 2024 at 08:00

Nature, Published online: 14 February 2024; doi:10.1038/s41586-024-07054-3

The Chinese Liver Cancer Atlas project depicts a panoramic genomic landscape of hepatocellular carcinoma, covering candidate coding and non-coding drivers, mutational signatures, extrachromosomal circular DNA, subclonal catastrophic events and detailed evolutionary history.