❌

Reading view

DrugMap: A quantitative pan-cancer analysis of cysteine ligandability

Cell

By: Mariko Takahashi， Harrison B. Chong， Siwen Zhang， Tzu-Yi Yang， Matthew J. Lazarov， Stefan Harry， Michelle Maynard， Brendan Hilbert， Ryan D. White， Heather E. Murrey， Chih-Chiang Tsou， Kira Vordermark， Jonathan Assaad， Magdy Gohar， Benedikt R. Dürr， Marianne Richter， Himani Patel， Gregory Kryukov， Natasja Brooijmans， Aliyu Sidi Omar Alghali， Karla Rubio， Antonio Villanueva， Junbing Zhang， Maolin Ge， Farah Makram， Hanna Griesshaber， Drew Harrison， Ann-Sophie Koglin， Samuel Ojeda， Barbara Karakyriakou， Alexander Healy， George Popoola， Inbal Rachmin， Neha Khandelwal， Jason R. Neil， Pei-Chieh Tien， Nicholas Chen， Tobias Hosp， Sanne van den Ouweland， Toshiro Hara， Lillian Bussema， Rui Dong， Lei Shi， Martin Q. Rasmussen， Ana Carolina Domingues， Aleigha Lawless， Jacy Fang， Satoshi Yoda， Linh Phuong Nguyen， Sarah Marie Reeves， Farrah Nicole Wakefield， Adam Acker， Sarah Elizabeth Clark， Taronish Dubash， John Ka

22 April 2024 at 08:00

DrugMap serves as a roadmap to develop covalent ligands for oncogenic drivers.

Deep whole-genome analysis of 494 hepatocellular carcinomas

Nature - Issue - nature.com science feeds

By: Lei Chen · Chong Zhang · Ruidong Xue · Mo Liu · Jian Bai · Jinxia Bao · Yin Wang · Nanhai Jiang · Zhixuan Li · Wenwen Wang · Ruiru Wang · Bo Zheng · Airong Yang · Ji Hu · Ke Liu · Siyun Shen · Yangqianwen Zhang · Mixue Bai · Yan Wang · Yanjing Zhu · Shuai Yang · Qiang Gao · Jin Gu · Dong Gao · Xin Wei Wang · Hidewaki Nakagawa · Ning Zhang · Lin Wu · Steven G. Rozen · Fan Bai · Hongyang Wang

14 February 2024 at 08:00

Nature, Published online: 14 February 2024; doi:10.1038/s41586-024-07054-3

The Chinese Liver Cancer Atlas project depicts a panoramic genomic landscape of hepatocellular carcinoma, covering candidate coding and non-coding drivers, mutational signatures, extrachromosomal circular DNA, subclonal catastrophic events and detailed evolutionary history.