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Identification of novel germline mutations in <i>FUT7</i> and <i>EXT1</i> linked with hereditary multiple exostoses

Oncogene, Published online: 17 December 2024; doi:10.1038/s41388-024-03254-3

Identification of novel germline mutations in FUT7 and EXT1 linked with hereditary multiple exostoses
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Synthesis of portimines reveals the basis of their anti-cancer activity

Nature, Published online: 20 September 2023; doi:10.1038/s41586-023-06535-1

A scalable total synthesis of portimines enables structural reassignment of portimine B and in-depth functional evaluation of portimine A, revealing that portimine A induces translation inhibition selectively in human cancer cells and is efficacious in vivo tumour-clearance models.
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Scientific discovery in the age of artificial intelligence

Nature, Published online: 02 August 2023; doi:10.1038/s41586-023-06221-2

The advances in artificial intelligence over the past decade are examined, with a discussion on how artificial intelligence systems can aid the scientific process and the central issues that remain despite advances.
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