In a population-based cohort of 191 children with diverse solid tumors, systems-level analyses unravel immune variation with age and tumor type and provide a reference for future precision immunotherapies tailored for the evolving immune systems of children.

Nature, Published online: 01 November 2023; doi:10.1038/s41586-023-06682-5

A pan-cancer epigenetic and transcriptomic atlas identifies epigenetic drivers associated with cancer transitions.