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Hepatocellular carcinoma detection via targeted enzymatic methyl sequencing of plasma cell-free DNA

Most Recent Articles: Clinical Epigenetics

By: Ping Guo， Hailing Zheng， Yihan Li， Yuntong Li， Yue Xiao， Jin Zheng， Xingqiang Zhu， Huan Xu， Zhi He， Qian Zhang， Jinchun Chen， Mingshan Qiu， Min Jiang， Pingguo Liu and Hongliang Chen

4 January 2023 at 08:00

Epigenetic variants carried by circulating tumor DNA can be used as biomarkers for early detection of hepatocellular carcinoma (HCC) by noninvasive liquid biopsy. However, traditional methylation analysis meth...

Spatial genomics maps the structure, nature and evolution of cancer clones

Nature - Issue - nature.com science feeds

By: Artem Lomakin · Jessica Svedlund · Carina Strell · Milana Gataric · Artem Shmatko · Gleb Rukhovich · Jun Sung Park · Young Seok Ju · Stefan Dentro · Vitalii Kleshchevnikov · Vasyl Vaskivskyi · Tong Li · Omer Ali Bayraktar · Sarah Pinder · Andrea L. Richardson · Sandro

9 November 2022 at 08:00

Nature, Published online: 09 November 2022; doi:10.1038/s41586-022-05425-2

A workflow centred around base-specific in situ sequencing generates detailed maps of, and can phenotypically characterize, the unique set of subclones of cancers.