Nature, Published online: 05 March 2025; doi:10.1038/s41586-025-08626-7
Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.
Nature, Published online: 05 March 2025; doi:10.1038/s41586-025-08689-6
In the Multicellularity Long Term Evolution Experiment, diploid yeast evolve to be tetraploid under selection for larger multicellular size, revealing how whole-genome duplication can arise due to its immediate benefits, persist under selection, and fuel long-term innovations via aneuploidy.
bioRxiv [Preprint]. 2025 Feb 17:2025.02.13.637721. doi: 10.1101/2025.02.13.637721.
ABSTRACT
Cell type-specific regulatory programs that drive type 1 diabetes (T1D) in the pancreas are poorly understood. Here we performed single nucleus multiomics and spatial transcriptomics in up to 32 non-diabetic (ND), autoantibody-positive (AAB+), and T1D pancreas donors. Genomic profiles from 853,005 cells mapped to 12 pancreatic cell types, including multiple exocrine sub-types. Beta, acinar, and other cell types, and related cellular niches, had altered abundance and gene activity in T1D progression, including distinct pathways altered in AAB+ compared to T1D. We identified epigenomic drivers of gene activity in T1D and AAB+ which, combined with genetic association, revealed causal pathways of T1D risk including antigen presentation in beta cells. Finally, single cell and spatial profiles together revealed widespread changes in cell-cell signaling in T1D including signals affecting beta cell regulation. Overall, these results revealed drivers of T1D progression in the pancreas, which form the basis for therapeutic targets for disease prevention.
PMID:40027657 | PMC:PMC11870426 | DOI:10.1101/2025.02.13.637721
Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08623-w
A rare variant burden analytical framework for Mendelian diseases was developed and applied to data from the 100,000 Genomes Project, identifying 69 probable new disease–gene associations.
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08398-6
PELO–HBS1L and SKI complexes in the human mRNA quality control pathway exhibit a synthetic lethal interaction and may represent novel targets for the development of cancer therapies.
Oncogene, Published online: 17 January 2025; doi:10.1038/s41388-024-03270-3
Evidence of DNA methylation heterogeneity and epipolymorphism in kidney cancer tissue samples
Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08388-8
Results from a comprehensive evaluation of the function of BRCA2 variants, particularly variants of uncertain significance, provide a useful resource to improve the clinical management of individuals who carry such genetic variants.
Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07380-6
Reducing greenhouse gas emissions, managing ecosystem health, and preventing biological invasions and biodiversity loss could help to reduce the burden of plant, animal and human diseases, especially when coupled with improvements to social and economic determinants of health.
Nature, Published online: 01 May 2024; doi:10.1038/s41586-024-07359-3
Quantitative multimodal 3D reconstruction of human pancreatic tissue at single-cell resolution reveals a high burden of multifocal, genetically heterogeneous pancreatic intraepithelial neoplasias in the normal adult pancreas.
Nature, Published online: 10 April 2024; doi:10.1038/d41586-024-01043-2
The bioengineered immune players called CAR T cells last longer and work better if pumped up with a large dose of a protein that makes them resemble stem cells.
Nature, Published online: 11 March 2024; doi:10.1038/d41586-024-00673-w
Therapy built on tumour-infiltrating lymphocytes is now being prepared for at least 20 people in the United States with advanced melanoma.
Nature, Published online: 15 January 2024; doi:10.1038/s41586-024-07050-7
Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes
Nature, Published online: 15 November 2023; doi:10.1038/s41586-023-06740-y
Experiments in mice show that expression of the oncogene SmoM2 induces basal cell carcinoma in the ear epidermis but not in the back skin, and that this difference in susceptibility is regulated by the extracellular matrix.
Nature, Published online: 12 September 2023; doi:10.1038/d41586-023-02861-6
SDG 14.5: at last, a breakthrough for the 2030 agenda
Nature, Published online: 27 July 2023; doi:10.1038/s41586-023-06455-0
Publisher Correction: Large language models encode clinical knowledge
Nature, Published online: 12 July 2023; doi:10.1038/s41586-023-06291-2
Med-PaLM, a state-of-the-art large language model for medicine, is introduced and evaluated across several medical question answering tasks, demonstrating the promise of these models in this domain.
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