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Systems-level immunomonitoring in children with solid tumors to enable precision medicine

Cell

By: Qi Chen · Binbin Zhao · Ziyang Tan · Gustav Hedberg · Jun Wang · Laura Gonzalez · Constantin Habimana Mugabo · Anette Johnsson · Erika Negrini · Laura Piñero Páez · Lucie Rodriguez · Anna James · Yang Chen · Jaromír Mikeš · Anna Karin Bernhardsson · Stefan Markus Reitzner · Ferdinand von Walden · Olivia O’Neill · Hugo Barcenilla · Chunlin Wang · Mark M. Davis · Lena-Maria Carlson · Niklas Pal · Klas Blomgren · Dirk Repsilber · Nikolas Herold · Tadepally Lakshmikanth · Per Kogner · Linda Ljungblad · Petter Brodin

20 January 2025 at 08:00

In a population-based cohort of 191 children with diverse solid tumors, systems-level analyses unravel immune variation with age and tumor type and provide a reference for future precision immunotherapies tailored for the evolving immune systems of children.

Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates

Nature Biotechnology - Issue - nature.com science feeds

By: Bin Liu · Xiaolong Dong · Chunwei Zheng · David Keener · Zexiang Chen · Haoyang Cheng · Jonathan K. Watts · Wen Xue · Erik J. Sontheimer

14 September 2023 at 08:00

Nature Biotechnology, Published online: 14 September 2023; doi:10.1038/s41587-023-01947-w

A DNA polymerase editing system offers advantages over prime editing.

Author Correction: An engineered influenza virus to deliver antigens for lung cancer vaccination

Nature Biotechnology - Issue - nature.com science feeds

By: Dezhong Ji · Yuanjie Zhang · Jiaqi Sun · Bo Zhang · Wenxiao Ma · Boyang Cheng · Xinchen Wang · Yuanhao Li · Yu Mu · Huan Xu · Qi Wang · Chuanling Zhang · Sulong Xiao · Lihe Zhang · Demin Zhou

13 July 2023 at 08:00

Nature Biotechnology, Published online: 13 July 2023; doi:10.1038/s41587-023-01884-8

Author Correction: An engineered influenza virus to deliver antigens for lung cancer vaccination

An engineered influenza virus to deliver antigens for lung cancer vaccination

Nature Biotechnology - Issue - nature.com science feeds

By: Dezhong Ji · Yuanjie Zhang · Jiaqi Sun · Bo Zhang · Wenxiao Ma · Boyang Cheng · Xinchen Wang · Yuanhao Li · Yu Mu · Huan Xu · Qi Wang · Chuanling Zhang · Sulong Xiao · Lihe Zhang · Demin Zhou

25 May 2023 at 08:00

Nature Biotechnology, Published online: 25 May 2023; doi:10.1038/s41587-023-01796-7

A cancer vaccine is delivered to the lung by an engineered attenuated influenza virus.